2014 Fiscal Year Final Research Report
Molecular target of urate-lowering drugs: Identification and functional characterization of a novel renal urate transporter URAT2
| Project/Area Number |
23590647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ANZAI Naohiko 獨協医科大学, 医学部, 教授 (70276054)
KIMURA Toru 杏林大学, 医学部, 助教 (30433725)
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| Research Collaborator |
WEMPE Michael F. 米国Colorado大学, 薬理学, 教授
TAEJARERNWIRIYAKUL Ormjai 獨協医科大学, 医学部
JAIYEN Chaliya 獨協医科大学, 医学部
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | トランスポーター / 尿酸 / 有機酸 / 痛風 / 尿酸降下薬 |
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| Outline of Final Research Achievements |
Organic anion transporter OAT10 was reported to mediate high-affinitiy nicotinate transport as well as low-affinitiy urate transport. Since I noticed that OAT10 may function as a second apical urate transporter URAT2, here I performed the experiments 1) to clarify the precise mechanisms of urate transport via URAT2 and 2) to accumulate the basic information for the new drug development for urate-lowering agents. As a results, I could find that URAT2 has an exchange mode for intracellular organic anions similar to URAT1 and broader substrate recognition to that of URAT1. In addition, I could get the fundamental structural information to raise novel urate-lowering agents.
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| Free Research Field |
薬理学
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