2014 Fiscal Year Final Research Report
Comprehensive study regarding adverse effects of opioid under palliative care
| Project/Area Number |
23590651
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Hoshi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NARITA Minoru 星薬科大学, 薬学部, 教授 (40318613)
|
|---|
| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Keywords | モルヒネ / 緩和医療 / 吐気 / 便秘 / 精神依存 |
|---|
| Outline of Final Research Achievements |
We found that olanzapine has beneficial profile to suppress opioid-induced emesis. This finding changes the strategy how opioid-induced emesis could be managed, and this change improve the patient's QOL. We also demonstrated that pirenzepine also suppressd opioid-induced emesis. Pirenzepine has much lessor adverse effects than those of olanzapine. Therefore, traials to investigate the effects of pirenzepine on opioid-induced emesis could be accepted in the Yokohana City University hospital.
We also demonstrated that morphine, oxycodone, and fentanyl induce constipation through different mechanisms, and these findings may help us to understand the characteristics of the constipation induced by each μ-opioid receptor agonist and improve the quality of life by reducing constipation in patients being treated for pain. In addition, we gave some information that opioid-induced psychic dependence could be established under chemotherapy-induced pain conditions.
|
| Free Research Field |
緩和医療
|
