2013 Fiscal Year Final Research Report
Identification of autoantibodies in acquired aplastic anemia
| Project/Area Number |
23590681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Naoki 札幌医科大学, 医学部, 教授 (10158644)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血液学 / 骨髄不全症候群 / 再生不良性貧血 / 自己免疫疾患 / 自己抗体 / 血清マーカー |
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| Research Abstract |
Acquired aplastic anemia (aAA) is a syndrome characterized by peripheral cytopenia with hypoplastic bone marrow. In this study, 8 autoantibodies expressed in aAA were identified. Among these autoantibodies, 3 antibodies were higher in patients with aAA than in normal volunteers. Moreover, responders to immunosuppressive therapy expressed at least one IgG-type autoantibody, whereas all non-responders did not express any IgG-type autoantibody. Furthermore, higher titers of IgG-type autoantibodies were found to be associated with better response rates to immunosuppressive therapy. These autoantibodies may be utilized to abstract patients associated with immune abnormality from bone marrow failure syndrome.
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