2014 Fiscal Year Final Research Report
Identification of novel non-tuberculous mycobacterium and analysis of the mechanism underlying its resistance to antibiotics
| Project/Area Number |
23590688
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTSUKA Kouki 杏林大学, 医学部, 助手 (70439165)
OHNISHI Hiroaki 杏林大学, 医学部, 准教授 (80291326)
WATANABE Takashi 杏林大学, 医学部, 教授 (00191768)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 微生物 / 抗酸菌 / 遺伝子 / 感受性 / 新菌種 / mycobacterium kyorinense |
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| Outline of Final Research Achievements |
The genetic analysis of 14 collected strains of Mycobacterium kyorinense clarified that they harbored polymorphism in 16S rRNA, suggesting the genetic diversity among the strains of this organism. In addition, analysis of Mycobacterium celatum, a species closely related to M. kyorinense, revealed that the sequences of several housekeeping genes of M. celatum type 2 are identical to those of M. kyorinense; therefore, we propose reclassification of M. celatum type 2 as M. kyorinense. Furthermore, the whole genome analysis of the type strain of M. kyorinense suggested that the mechanism underlying the resistance to antibiotics of this organism is significantly different from those of M. tuberculosis.
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| Free Research Field |
医歯薬学
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