2013 Fiscal Year Final Research Report
New method of evaluation and diagnosis for DIC using endothelial cell-derived microparticles
| Project/Area Number |
23590694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Tomoki 関西医科大学, 医学部, 准教授 (70434826)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管内皮細胞由来マイクロパーティクル / HMGB1 / リコンビナントトロンボモジュリン / SIRS / DIC / 造血器腫瘍 |
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| Research Abstract |
We found that, although TRAP-stimulated platelets could induce up-regulation of some molecules such as CD40, CD80, CD83, CD86 and HLA-DR to some extent, the addition of MPs further increased this expression compared with expression induced by TRAP-stimulated platelets. In addition, the enhancement of expression of these molecules in response to TRAP-stimulated platelets or MPs was completely inhibited by anti-CD154 antibody. For DIC patients with hematologic malignancy, univariate analysis showed that PT, fibrinogen, CRP, PDMP, EDMP, sCD40L, IL-6, TNF-alpha, RANTES and MCP-1 were significantly associated with HMGB1. DIC patients exhibited significant decrease in HMGB1 levels after rTM therapy. In addition, the levels of platelet activation markers and cytokines were significantly decreased after rTM therapy in DIC patients. Our findings indicate the role of EDMP and HMGB1 in DIC patients with hematologic malignancy.
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Research Products
(15 results)
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[Journal Article] Aliskiren, a direct rennin inhibitor, improves vascular endothelial function in patients on hemodialysis independent of antihypertensive effect-a pilot study-2013
Author(s)
Hidekazu Moriya, Shuzo Kobayashi, Takayasu Ohtake, Daimu Tutumi, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Sumi Hidaka, Shosaku Nomura
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Journal Title
Kidney & Blood Pressure Research
Volume: vol.37, no.2-3
Pages: 190-198
DOI
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[Presentation] 慢性骨髄性白血病患者におけるサイトカイン・ケモカイン・可溶性分子・止血凝固系マーカーの評価2012
Author(s)
石井一慶, 魚嶋伸彦, 前田裕弘, 堀田雅章, 吉村英晃, 藤田真也, 中道尚人, 宮地理彦, 伊藤量基, 桂田達也, 浦瀬文明, 林邦雄, 野村昌作
Organizer
第74回日本血液学会学術集会
Place of Presentation
国立京都国際会館(京都市左京区)
Year and Date
2012-10-19
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