2013 Fiscal Year Final Research Report
Developments of diagnostics for Mild Cognitive Impairment by patients serum and inhibition of the disease progress with vitamin D
| Project/Area Number |
23590697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUENAGA Midori 徳島文理大学, 薬学部, 助教 (00389181)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOI Yoshio 福岡大学, 医学部, 教授 (90291822)
UEHARA Yoshinari 福岡大学, 医学部, 講師 (70373149)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アルツハイマー病 / アミロイドベータ蛋白 / ベータシート構造 / オリゴマー形成 / 蛋白凝集 / ビタミンＤ２ / ビタミンＤ３ / プリオン蛋白 |
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| Research Abstract |
Aggregated amyloid-beta is a pathological feature in Alzheimer's disease(AD) and mild cognitive impairment(MCI) is an early stage of AD. Up to date, there is no diagnostics of MCI by patients serum. We found that the concentration of 25(OH)V-D3 in serum with MCI is lower than that of normal volunteers, and there is no differences in the concentration of 1,25(OH)2V-D3 between them. We suggest that the serum concentration of 25(OH)V-D3 is useful for the diagnostics of MCI. Unexpectedly, 25(OH)V-D3 showed no inhibitory effects for the aggregation in vitro, and rather promoted the aggregation.
PrPsc is the responsible protein to cause scrapie, which derived from the conformational transition of PrPc in normal brain. Oligomerization of PrPc is a pre-stage of PrPsc. We found that V-D3 could not break the oligomerization, however VD2 could break the oligzation, suggesting that VD2 is useful for scrapie therapy.
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Author(s)
Kiyohara C, Miyake Y, Koyanagi, M. Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae Fukuoka Kinki Parkinson's Disea e Study Group
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Journal Title
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Author(s)
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Journal Title
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Volume: 68
Pages: 10011-10029
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Author(s)
Miyake Y, Tanaka K, Fukushima W Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Study Group TF
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Journal Title
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Author(s)
Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M; Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
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Volume: 18
Pages: 557-561
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[Journal Article] Refractory acute disseminated encephalomyelitis with anti-galactocerebroside antibody2012
Author(s)
Samukawa M, Hirano M, Tsugawa J, Sakamoto H, Tabata E, Takada K, Kuwahara M, Suzuki S, Kitada M, Yamada T, Hara H, Tsuboi Y, Nakamura Y, Kusunoki S
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Journal Title
Neurosci. Res
Volume: 74
Pages: 284-289
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