2014 Fiscal Year Final Research Report
Exploring the pathophysiology of dyslipidemia using cITP lipoprotein analysis
| Project/Area Number |
23590699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKU Keijiro 福岡大学, 医学部, 教授 (40183371)
MATSUNAGA Akira 福岡大学, 医学部, 教授 (60221587)
MIURA Shin-ichiro 福岡大学, 医学部, 准教授 (20343709)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | リポ蛋白質分析 / 脂質異常症 / キャピラリー等速電気泳動法 / 低HDL-C血症 / HDL治療 / 合成HDL / LDL亜分画 / HDL亜分画 |
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| Outline of Final Research Achievements |
High-density lipoprotein (HDL) has anti-atherogenic properties. Capillary isotachophoresis (cITP) separates plasma lipoproteins into 3 HDL subfractions and 3 LDL subfractions. In the present study, first, we show that that cITP lipoprotein analysis is useful in the differential diagnosis of hypoalphalipoproteinemia (HA). Next, we show that recombinant HDL (a complex of apolipoprotein AI mimetic peptide and phospholipids) had a significant effect on the remodeling of LDL subfractions in WHHL rabbits, an animal model of human familial hypercholesterolemia, indicating that remodeling effects on LDL subfractions is one of the mechanisms of the anti-atherogenic effects of recombinant HDL. Finally, we found that in female subjects with increased visceral fat, the subcutaneous fat area is associated with cITP sHDL, indicating that subcutaneous fat may have an effect on HDL metabolism.
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| Free Research Field |
リポ蛋白質代謝と動脈硬化
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