2013 Fiscal Year Final Research Report
Targeting acid sensing ion channels as a novel treatment for joint pain
| Project/Area Number |
23590713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 関節痛 / 鎮痛薬 / 酸 / イオンチャネル |
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| Research Abstract |
Synovial fluid in inflamed or degenerated joint shows a drop in pH, which activates proton-gated ion channels in nociceptors. The purpose of this study was to clarify the roles of proton-gated ion channels in joint pain using selective antagonists for these ion channels in animal models. Among antagonists for ASIC1a, ASIC3, and TRPV1, only ASIC3 antagonist reduced hyperalgesia of the legs in osteoarthritis pain model and acid induced joint pain model. Furthermore, ASIC3 antagonist prevented cartilage damage in osteoarthritis model. ASIC3 antagonist is a novel and promising drug for joint pain.
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Research Products
(8 results)
