2013 Fiscal Year Final Research Report
Investigation for the mechanism of neuropathic pain on spinal pain transmission.
| Project/Area Number |
23590718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKURADA Shinobu 東北薬科大学, 薬学部, 教授 (30075816)
MIZOGUCHI Hirokazu 東北薬科大学, 薬学部, 准教授 (30360069)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経障害性疼痛 / 脊髄 / 疼痛伝達物質 / 受容体 / マイクロダイアリシス |
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| Research Abstract |
Neuropathic pain is one of the serious painful syndrome in clinic. However, its mechanism is still unknown. In this project, to describe the mechanism of the neuropathic pain involvement of various neurotransmitters and its receptors on the central and peripheral nervous system was investigated in the animal model for the nerve-injured neuropathy. As the results, it was found that various neurotransmitters may play a different role for the expression and maintenance of allodynia in the neuropathic pain state.
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[Journal Article] Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine2011
Author(s)
Hirokazu Mizoguchi, Takaaki Komatsu, Yoko Iwata, Chizuko Watanabe, Hiroyuki Watanabe, Tohru Orito, Soh Katsuyama, Akihiko Yonezawa, Kenji Onodera, Tsukasa Sakurada, Shinobu Sakurada
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Journal Title
Neuroscience Letters
Volume: 495
Pages: 83-87
DOI
Peer Reviewed
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