2013 Fiscal Year Final Research Report
Pathophysiological and pharmacological assessment of synaptic transmission in chronic pain states
| Project/Area Number |
23590720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Hideki 名古屋市立大学, 大学院薬学研究科, 教授 (00080200)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経障害性疼痛 / シナプス伝達 / 脊髄スライス / パッチクランプ / グリシントランスポーター / C-線維誘発性フィールド電位 / ドネペジル / ミルナシプラン |
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| Research Abstract |
In chronic pain conditions including neuropathic and inflammatory pain, enhanced efficacy of synaptic transmission in the spinal dorsal horn contributes largely to hyperalgesia and tactile allodynia. Moreover, patients with chronic pain frequently express various symptoms of neuropsychologic impairment, including chronic fatigue, depression, anxiety, sleep disturbance and cognitive deficits, which further affects quality of life. In the study presented here, in particular focusing on monoamines, glycine and acetylcholine, behavioral studies as well as in vivo and in vitro electrophysiological studies were made to explore pathophysiology of neuropathic pain and the effects of some potentially analgesic drugs, which we consider is important to obtain crucial information for developing novel analgesic drugs to treat patients with chronic pain.
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