2013 Fiscal Year Final Research Report
Mechanism of the demyelination and regulation by the microglia in neuropathic pain
| Project/Area Number |
23590727
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Foundation for Biomedical Research and Innovation (2013)
Osaka Dental University (2011-2012) |
|---|
Principal Investigator |
MAEDA Mitsuyo 公益財団法人先端医療振興財団, 先端医療センター研究所再生医療研究部, 上席研究員 (40122080)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUWA Fumihiko 大阪歯科大学, 歯学部, 教授 (30067178)
UEMURA Mamoru 大阪歯科大学, 歯学部, 助教 (30351472)
TAKEMURA Akimichi 大阪歯科大学, 歯学部, 准教授 (00155045)
TODA Isumi 大阪歯科大学, 歯学部, 講師 (20197891)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 神経因性疼痛 / LPA1 / ミクログリア / 脊髄後角 / 脱髄 |
|---|
| Research Abstract |
We investigated the change of the lysophosphatidic acid receptor-1 (LPA-1) in the posterior horn of spinal cord known as a substance which participates in the pain and demyelination at the time of a neuropathic pain.The onset of LPA-1 mRNA was within postoperative 6 hour. LPA-1 immunoreactivity was observed in the cytoplasm of the oligodendrocyte, astrocyte of a posterior horn of spinal cord, and also, the protoplasmic membrane of the ganglion cell of a dorsal root ganglion, Schwann-cell, and myelin sheath. In injured side, the number of LPA-1 immune-positive cells increased at 3, 7days after injury. These LPA-1 immunopositive cells may be relevant to the onset of neuropathic pain.
Microglia were considered to be induces in activation, amplification and chronic pain through the ATP release by produced LPA at injured side.
|
