2013 Fiscal Year Final Research Report
Studies of the mechanism and discovery of animal model in neuropathic pain
| Project/Area Number |
23590731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Fukuoka University |
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Principal Investigator |
HONDA Kenji 福岡大学, 薬学部, 助教 (60140761)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ryo 福岡大学, 薬学部, 講師 (80122696)
TAKANO Yukio 福岡大学, 薬学部, 教授 (50113246)
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| Co-Investigator(Renkei-kenkyūsha) |
MIGITA Keisuke 弘前大学, 大学院医学研究科, 助教 (10352262)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経障害性疼痛 / ケモカイン / ミクログリア細胞 / GABA作動性神経 / ムスカリン受容体 / アセチルコリン / 帯状回 |
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| Research Abstract |
Pain control is very important. The mechanism of pain is not fully understood. Therefore, we examined the mechanisms of neuropathic pain and the discovery to neuropathic pain in the central nervous system.
(1) We examined the functional role of chemokines, chemotactic cytokine ligand-1(CCL-1)in neuropathic pain. Pre-administrations of anti-CCL-1 antibody in the spinal cord inhibited the allodynia. This result supports that spinal CCL-1 contributes to the development of neuropathic pain. (2) We demonstrated how the muscarinic receptors in the brain involve in neuropathic pain. Activation of muscarinic M1 receptors in the the cinglate cortex attenuated the neuropathic pain and the analgesic effect was mediated by activation of GABAergic neuron. (3) Cholinesterase inhibitor donepezil and galantamine reduced hyperalgesia via central muscarinic receptors in the neuropathic pain model. Donepezil and galantamine may be useful in the therapeutic outcome in the management of neuropathic pain.
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Research Products
(19 results)
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[Journal Article] CCL-1 in the spinal cord contributes to neuropathic pain induced by nerve injury2013
Author(s)
Nozomi Akimoto, Kenji Honda, Daisuke Uta, Kaoru Beppu, Yuichi Ushijima, Yu Matsuzaki, Shigeto Nakashima, Mizuho A. Kido, Keiji Imoto, Yukio Takano , Mami Noda
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Journal Title
Cell & Death Disease
Volume: Vol. 4
Pages: e679
DOI
Peer Reviewed
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[Journal Article] Estrogen deficiency impairs sensitivity of the baroreceptor reflex and vasomotor functions in the aorta2012
Author(s)
Akiko Chishaki, Yasutoshi Hirabara, Kyoko Takeyoshi, Shiori Nasu, Sayo Tsumura, Sayaka Morimoto, Kohji Tominaga, Hideki Shuto, Yasufumi Kataoka, Kenji Honda, Ryo Saito, Yukio Takano
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Journal Title
Pharmaceutical Bulletin of Fukuoka Univ
Volume: Vol. 12
Pages: 1-7
Peer Reviewed
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