2013 Fiscal Year Final Research Report
Behavioral study on analgesic effect of ATP sensitive potassium channel openers
| Project/Area Number |
23590732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARA Koji 産業医科大学, 医学部, 講師 (20331001)
TERADA Tadanori 産業医科大学, 医学部, 助教 (10399206)
NAKAMURA Motohiro 産業医科大学, 医学部, 助教 (30461578)
SATA Takeyoshi 産業医科大学, 医学部, 教授 (60128030)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 行動薬理学 / 鎮痛薬 / 神経障害性疼痛 |
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| Research Abstract |
The analgesic effects of ATP sensitive potassium channel openers were examined using a rat neuropathic pain model. Chronic constriction injury to the sciatic nerve was induced in male Sprague–Dawley rats. Structurally distinct drugs, diazoxide, pinacidil, and nicorandil were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia. These drugs applied spinally and supraspinally attenuated mechanical and cold hyperalgesia in a dose-dependent manner, but they had no effect on thermal hyperalgesia. The ATP sensitive potassium channel openers may exert antihyperalgesic effects both in the spinal cord and brain.
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