2013 Fiscal Year Final Research Report
Identification and molecular epidemiological analysis of emerging clones of community-acquired MRSA
| Project/Area Number |
23590746
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUMI Ayako 札幌医科大学, 医学部, 准教授 (10363699)
URUSHIBARA Noriko 札幌医科大学, 医学部, 講師 (80396308)
GHOSH Souvik 札幌医科大学, 医学部, 助教 (30597175)
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| Project Period (FY) |
2011 – 2013
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| Keywords | MRSA / 市中感染 / 分子疫学 |
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| Research Abstract |
To investigate prevalence in Japan of community-acquired MRSA (CA-MRSA) which is concerned for its global spread, and their molecular epidemiological characteristics, we analyzed clinical isolates from the Sapporo Medical University Hospital (601 isolates, 2008-2010) and those from local hospitals/clinics in Hokkaido prefecture (outpatients, 422 isolates in 2011). As a result, SCCmec types IV and V, which are genetic markers of CA-MRSA, were detected in 4.3% and 17.1% in the isolates from the University Hospital and local hospitals/clinics, respectively. Among them, seven isolates were revealed to be USA300 clone which is dominant in the US (ST8, positive for PVL and ACME), and many ST5 MRSA having ACME were detected. These emerging CA-MRSA clones were confirmed to be distributed in Japan.
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