2013 Fiscal Year Final Research Report
The association of thigh muscle area and CT attenuation measured by CT with metabolic diseases
| Project/Area Number |
23590748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Osaka City University |
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Principal Investigator |
SATO KYOKO 大阪市立大学, 医学(系)研究科(研究院), 講師 (00381989)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Tomoshige 大阪市立大学, 大学院医学研究科, 准教授 (10381980)
ENDO Ginji 大阪市立大学, 大学院医学研究科, 教授 (20160393)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 疫学 / 骨格筋 / 代謝性疾患 |
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| Research Abstract |
We examined whether a single-slice thigh muscle area measured by computed tomography (CT) can be substituted for thigh muscle volume measured with contiguous magnetic resonance imaging scans. This validation study consisted of 57 subjects. Correlation between volume and area was strong (0.864, p<0.001).
In our cohort study, we analyzed the association of thigh muscle area and CT attenuation measured by CT with metabolic diseases in 1366 men and women. In multivariate analyses, the elevated area per kg of body weight (area/weight) was associated with the low prevalence of impaired fasting glucose (IFG) or type 2 diabetes, high normal blood pressure (BP) or hypertension, and hypertriglyceridemia. The elevated CT attenuation was associated with the low prevalence of IFG or type 2 diabetes, high normal BP or hypertension, hypertriglyceridemia, and hypo-high-density lipoproteinemia. The elevated area/weight or CT attenuation was related with the low insulin resistance among men or women.
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