Effects of n-3 unsaturated fatty acid on ischemic heart disease: evaluation of LDL choesterol function

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Nihon University
• Principal Investigator: TANI Shigemasa 日本大学, 医学部, 准教授 (30451347)
• Co-Investigator(Renkei-kenkyūsha): NAGAO Ken 日本大学, 医学部研究所, 教授 (90207978) ; HIRAYAMA Atsushi 日本大学, 医学部, 教授 (50459880)
• Project Period (FY): 2011 – 2013
• Keywords: エイコサペンタエン酸 / ドコサヘキサエン酸 / 冠動脈疾患 / 血清脂質

Research Abstract

Hypertriglyceridemic subjects were randomly assigned to a control group or an EPA group.In the EPA group,the serum LDL-C and HDL-C levels remained unchanged, but there was a significant increase in LDL size and a significant decrease in TG-rich lipoproteins (TRLs) levels. Elevation of EPA/AA was independent variable associated with the increase in LDL size. Negative correlations were found between TRLs and LDL particle size. EPA administration increases LDL size by improving TG metabolism, and EPA/AA may be useful markers of increased LDL size.The cross-sectional study suggested that higher serum levels of EPA and DHA derived from fish consumption are associated with lower coronary artery disease prevalence even in an urban environment in Japan. Higher EPA and DHA levels were independent variables of a higher apoA-1 level.

Research Products

• [Journal Article] Association of n-3 polyunsaturated fatty acids with soluble thrombomodulin as a marker of endothelial damage : A cross-sectional pilot study (2014)
  • Author(s): Kawauchi K, Tani S, Nagao K, Hirayama A
  • Journal Title: J Cardiol
  • DOI: 10.1016/j.jjcc.2014.02.004
  • Peer Reviewed
• [Journal Article] Association of atherosclerosis-related markers and its relationship to n-3 polyunsaturated fatty acids levels with a prevalence of coronary artery disease in an urban area in Japan (2013)
  • Author(s): Tani S, Nagao K, Hirayama A
  • Journal Title: Heart Vessels Volume: (Epub ahead of print, PubMed PMID : 24309896)
  • Peer Reviewed
• [Journal Article] Highly purified eicosapentaenoicacid may increase low-density lipoprotein particle size by improving triglyceridemetabolism in patients with hypertriglyceridemia (2013)
  • Author(s): Tani S, Nagao K, Matsumoto M, Hirayama A
  • Journal Title: Circ J Volume: 77 Pages: 2349-57
  • Peer Reviewed
• [Presentation] Highly purified eicosapentaenoic acid may increase the low-density lipoprotein particle size by improving triglyceride metabolism in patients with hypertriglyceridemia (2013)
  • Author(s): Tani, Nagao, Matsumoto, Onikura, Ashida, Kawauchi, Hirayama
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2013-09-02
• [Presentation] Potential preventive effects of n-3 polyunsaturated fatty acids on vascular endothelial damage : evaluation with soluble thrombomodulin (2013)
  • Author(s): Kawauchi, Tani, Matsumoto, Onikura, Nagao,, Ashida, Hirayama
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2013-09-02
• [Presentation] Fish Consumption-derived High Eicosapentaenoic Acid / Arachidonoenic Acid Ratio May Reduce Atherosclerotic Cardiovascular Risk : Implication of Atherosclerotic Cardiovascular Biomarker (2013)
  • Author(s): Tani, Nagao, Kawamata, Furuya, Takahashi, Iida, Matsumoto, Kobari, Washio, Kazato, Hirayama
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-17
• [Presentation] Highly Purified Eicosapentaenoic Acid May Increase the LDL-particle Size by Improving Triglyceride Metabolism in Patients with Hypertriglyceridemia (2013)
  • Author(s): Tani, Nagao, Kawamata, Furuya, Takahashi, Iida, Matsumoto, Kobari, Washio, Hirayama
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-16
• [Presentation] Association of N-3 Polyunsaturated Fatty Acids and Coronary Artery Disease Morbidity with Atherosclerosis-Related Markers (2013)
  • Author(s): Tani, Nagao, Kawamata, Furuya, Takahashi, Iida, Matsumoto, Kobari, Washio, Kazato, Hirayama
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-16
• [Presentation] 平山内科パネルディスカッション2:冠動脈イベントを予測できるか?血清エイコサペンタエン酸/アラキドンサン酸(EPA/AA)比は冠動脈疾患発症の予測バイオマーカーになるか (2012)
  • Author(s): 谷, 長尾, 川俣, 古屋, 高橋, 飯田, 松本, 小張, 鷲尾, 風戸
  • Organizer: 第26回日本冠疾患学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-12-05