2013 Fiscal Year Final Research Report
Studies on fever with unknown origin (FUO0 in South and South East Asia
Project/Area Number |
23590770
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Public health/Health science
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Research Institution | Hokkaido University |
Principal Investigator |
MORIMATSU Kumiko (吉松 組子) 北海道大学, 医学(系)研究科(研究院), 准教授 (90220722)
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Co-Investigator(Renkei-kenkyūsha) |
ARIKAWA Jiro 北海道大学, 大学院医学研究科, 教授 (10142704)
SHIMIZU Kenta 北海道大学, 大学院医学研究科, 助教 (20466840)
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Project Period (FY) |
2011 – 2013
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Keywords | ハンタウイルス感染症 / レプトスピラ / HEV / 不明熱 |
Research Abstract |
The investigation of hantavirus-associated infectious diseases in Southeast Asia and South Asia had been conducted. Throughout the investigation, many examples of fever of unknown origin (FUO) were found from febrile diseases. In this report, it aimed to clarify FUO in this region. Febrile patient sera (not dengue fever and a flu victim) and wild rodent sera as a career of infectious agents conducted investigation of causative agent of febrile illness in Vietnam and Sri Lanka. Finally, it was suggested that seropositive cases against pathogenic organs, such as hepatitis E virus (HEV), leptospira, and hantaviruses are found from a part of FUO patient. Furthermore, it was shown that rodents in both countries also possessed these agents. Therefore rodents were able to be sources of these zoonotic agents.
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Research Products
(33 results)
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[Journal Article] Distinct genetic characteristics of Sri Lankan Rattus and Bandicota (Murinae, Rodentia) inferred from mitochondrial and nuclear markers2014
Author(s)
Yasuda PS, Gamage CD, Koizumi N, Nishio S, Isozumi R, Shimizu K, Koma T, Amada T, Suzuki H, Yoshimatsu K, Arikawa J
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Journal Title
Genes Genet. Syst
Volume: (in press)
Peer Reviewed
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[Journal Article] Development of an immunochromatography strip test based on truncated nucleocapsid antigens of three representative hantavir1u3se. sK. oma T, Yoshimatsu K, Taruishi M2014
Author(s)
Amada T, Yoshimatsu K, Koma T, Shimizu K, Gamage CD, Shiokawa K, Nishio S, Ahlm C, Arikawa J
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Journal Title
Virology Journal
Volume: (in press)
Peer Reviewed
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[Journal Article] Cross-reactivity of secondary antibodies against African rodents and application for sero-surveillance2013
Author(s)
Nakamura I, Hang'ombe BM, Sawa H, Kobayashi S, Orba Y, Ishii A, Thomas Y, Isozumi R, Yoshimatsu K, Mweene AS, Takada A, Sugimoto C, Arikawa J
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Journal Title
J Vet Med Sci
Volume: 75
Pages: 819-825
Peer Reviewed
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[Journal Article] Susceptibility of laboratory rats against genotypes 1, 3, 4, and rat hepatitis E viruses2013
Author(s)
Li TC, Yoshizaki S, Ami Y, Suzaki Y, Yasuda SP, Yoshimatsu K, Arikawa J, Takeda N, Wakita T
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Journal Title
Vet Microbiol
Volume: 163
Pages: 54-61
Peer Reviewed
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[Journal Article] Rapid, whole blood diagnostic test for detecting anti-hantavirus antibody in rats2013
Author(s)
Amada T, Yoshimatsu K, Yasuda SP, Shimizu K, Koma T, Hayashimoto N, Gamage CD, Nishio S, Takakura A, Arikawa J
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Journal Title
J Virol Methods
Volume: 193
Pages: 42-49
Peer Reviewed
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[Journal Article] The N-terminus of the Montano virus nucleocapsid protein possesses broadly cross-reactive conformation-dependent epitopes conserved in rodent-borne hantaviruses2012
Author(s)
Saasa N, Yoshida H, Shimizu K, Sanchez-Hernandez C, Romero-Almaraz MD, Koma T, Sanada T, Seto T, Yoshii K, Ramos C, Yoshimatsu K, Arikawa J, Takashima I, Kariwa H
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Journal Title
Virology
Volume: 428
Pages: 48-57
Peer Reviewed
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[Journal Article] Studies on hantavirus infection in small mammals captured in southern and central highland area of Vietnam2012
Author(s)
Luan VD, Yoshimatsu K, Endo R, Taruishi M, Huong VT, Dat DT, Tien PC, Shimizu K, Koma T, Yasuda SP, Nhi L, Arikawa J
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Journal Title
J Vet Med Sci
Volume: 74
Pages: 1155-1162
Peer Reviewed
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[Journal Article] A survey of rodent-borne pathogens carried by wild Rattus spp. in Northern Vietnam2012
Author(s)
Koma T, Yoshimatsu K, Yasuda SP, Li T, Amada T, Shimizu K, Isozumi R, Mai LT, Hoa NT, Nguyen V, Yamashiro T, Hasebe F, Arikawa J
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Journal Title
Epidemiol Infect
Pages: 1-9
Peer Reviewed
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[Journal Article] Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection2012
Author(s)
Koma T, Yoshimatsu K, Taruishi M, Miyashita D, Endo R, Shimizu K, Yasuda SP, Amada T, Seto T, Murata R, Yoshida H, Kariwa H, Takashima I, Arikawa J
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Journal Title
J Virol Methods
Volume: 185
Pages: 74-81
Peer Reviewed
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[Journal Article] Characterization of self-assembled virus-like particles of rat hepatitis E virus generated by recombinant baculoviruses2011
Author(s)
Li TC, Yoshimatsu K, Yasuda SP, Arikawa J, Koma T, Kataoka M, Ami Y, Suzaki Y, Mai le TQ, Hoa NT, Yamashiro T, Hasebe F, Takeda N, Wakita T
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Journal Title
J Gen Virol
Volume: 92
Pages: 2830-2837
Peer Reviewed
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[Journal Article] Serological evidence of Thailand virus-related hantavirus infection among suspected leptospirosis patients in Kandy, Sri Lanka2011
Author(s)
Gamage CD, Yasuda SP, Nishio S, Kularatne SA, Weerakoon K, Rajapakse J, Nwafor-Okoli C, Lee RB, Obayashi Y, Yoshimatsu K, Arikawa J, Tamashiro H
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Journal Title
Jpn J Infect Dis
Volume: 64
Pages: 72-75
Peer Reviewed
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[Presentation] ラットE型肝炎ウイルスは人獣共通感染症の病原体か?2013
Author(s)
清水健太, 濱口杉大, Cuong Ngo Chi, 李天成, 吉松組子, 津田祥美, 塩川愛絵, 西尾佐奈恵, 吉田レイミント, 有吉紅也, 有川二郎
Organizer
第61回日本ウイルス学会学術集会
Place of Presentation
神戸国際会議場(神戸市)
Year and Date
20131110-12
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[Presentation] Application of recombinant LigA and LipL32 to the lateral flow immunoassay for the detection of pathogenic Leptospira spp. specific IgG in rodent sera2013
Author(s)
Shiokawa K, Gamage CD, Koizumi N, Nishio S, Koarashi Y, Tsuda Y, Shimizu K, Yoshimatsu K, Arikawa J
Organizer
8th Scientific Meeting of International Leptospirosis Society
Place of Presentation
Centennial Hall Kyushu University School of Medicine, Fukuoka, Japan
Year and Date
20131008-11
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[Presentation] Development of an Immunochromatography Strip Test for Detecting Anti-hantavirus Antibody in Rodent and Human Sera by Using an N-terminal Common Antigenic Site of Hantavirus N protein2013
Author(s)
Arikawa J, Amada T, Yoshimatsu K, Hayashimoto N, Koma T, Shimizu K, Gamage CD, Shiokawa K, Nishio S, Ahlm C, Takakura A
Organizer
IX International Conference on HFRS HPS & Hantaviruses
Place of Presentation
Beijing International Convention Center, Beijing, CHINA
Year and Date
20130605-07
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[Presentation] Role of Neutrophils in the Induction of Pulmonary Edema during Hantavirus Infection in C.B-17Scid Mice2013
Author(s)
Yoshimatsu K, Koma T, Nagata N, Sato Y, Shimizu K, Amada T, Nishio S, Hasegawa H, Arkawa J
Organizer
IX International Conference on HFRS HPS & Hantaviruses
Place of Presentation
Beijing International Convention Center, Beijing, CHINA
Year and Date
20130605-07
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[Presentation] Development of Immunochromatographic Rapid Test for the Detection of IgG Antibodies Specific to HFRS and HPS Hantaviruses in Human and Rodent Serum. Mini-symposium on Emerging and Re-emerging Viral Diseases in Asia2012
Author(s)
T akako Amada, Nobuhito Hayashimoto, Kumiko Yoshimatsu, Shumpei Yasuda, Kenta Shimizu, Takaaki Koma, Rie Isozumi, Akira Takakura, Jiro Arikawa
Organizer
46th Joint Working Conference on Viral Diseases, The Japan-United States Cooperative Medical Science Program
Place of Presentation
Beppu, Japan
Year and Date
20120619-20
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[Presentation] Persistence of Seoul virus in natural host (Rattus norvegicus)2012
Author(s)
Kumiko Yoshimatsu, Shumpei P. Yasuda, Kenta Shimizu, Takaaki Koma, Takako Amada, Tetsu Yamashiro, Futoshi Hasebe, Nguyen Thuy Hoa, Le Thi Quynh Mai, Jiro Arikawa
Organizer
The 9th Japan-China International Conference of Virology
Place of Presentation
Sapporo, Japan
Year and Date
20120612-13
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[Presentation] Epidemiology of rat hepatitis E virus infection in human and rodents in Vietnam2012
Author(s)
Kenta Shimizu, Tian-Cheng Li, Shumpei P Yasuda, Kumiko Yoshimatsu, Takaaki Koma, Futoshi Hasebe, Tetsu Yamashiro, Nguyen Thuy Hoa, Le Thi Quynh Mai, Koya Ariyoshi, Jiro Arikawa
Organizer
The 9th Japan-China International Conference of Virology
Place of Presentation
Sapporo, Japan
Year and Date
20120612-13
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