2013 Fiscal Year Final Research Report
Epidemiological study on soluble Fas as a apoptotic factor and IGF-1 as a cellular growth factor in relation to hemorragic cerebrovascular diseases
| Project/Area Number |
23590776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SANKAI Tomoko 筑波大学, 医学医療系, 准教授 (10241829)
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| Co-Investigator(Renkei-kenkyūsha) |
ISO Hiroyasu 大阪大学, 医学系研究科, 教授 (50223053)
KITAMURA Akihiko 大阪大学, 医学系研究科, 准教授 (80450922)
YAMAGISHI Kazumasa 筑波大学, 医学医療系, 講師 (20375504)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 疫学 / 出血性脳血管疾患 / アポトーシス関連因子 / 細胞増殖因子 / 脳内出血 / くも膜下出血 / リスクファクター |
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| Research Abstract |
To investigate the relation between apoptpsis, 'cell death', and hemorrhagic stroke without arteriosclerosis among Japanese, a nested case-control study was conducted on approximately nine thousand persons lived in three communities which were long-term follow-up cohorts existed in Akita, Ibaraki, Kochi, respectively. During follow-up from1984, 54 incident cases whose onset age was 69 and below occurred. In this study, 54 cases and 108 controls matched with cases for living area, sex, age, and follow-up periods were selected, and sFas as an apoptosis-related factor and IGF-1 as a cellular growth factor were measured in sera prepared from blood collection before onset of stroke and stored in deep freezers. In conclusion, the present study suggests that sFas did not accept relation, but a possibility that lack of IGF-1 was improving the brittleness of the aneurysm wall of cerebral arteries as a pathogenic mechanism of subarachnoid hemorrhage.
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[Presentation] 長期間の重点的な脳卒中予防対策は、脳卒中以外の生活習慣病医療費の上昇をも抑制する2013
Author(s)
山岸良匡, 若林洋子, 稲川三枝子, 鳥海佐和子, 廣瀬久美子, 山海知子, 梅澤光政, 丸山智子, 堀幸, 久保佐智美, 緒方剛, 大久保一郎, 磯博康
Organizer
第72回日本公衆衛生学会総会
Place of Presentation
三重県津市
Year and Date
2013-10-24
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[Presentation] 地域住民における隠れ高血圧の頻度とその関連因子2013
Author(s)
大平哲也, 今野弘規, 崔仁哲, 丸山智子, 久保佐智美, 北村明彦, 木山昌彦, 梶浦貢, 岡田武夫, 山岸良匡, 梅澤光政, 長尾匡則, 山海知子, 谷川武, 磯博康
Organizer
第72回日本公衆衛生学会総会
Place of Presentation
三重県津市
Year and Date
2013-10-23
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