2014 Fiscal Year Final Research Report
Relationship of plasma asymmetrical dimethylarginine to coronary artery calcification in elderly population
| Project/Area Number |
23590792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 成人保健 / 心腎連関 |
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| Outline of Final Research Achievements |
Subjects aged 60-79 were examined with physical examinations, life-style questionnaires, laboratory assessment, Intima-media thicness (IMT) and coronary calcium score(CCS) using standardized methods. Plasma samples were stored at -80°C, and concentration of ADMA was determined using a validated high-throughput liquid chromatographic tandem mass spectrometric assay. The average concentrations and standard deviation (SD) of plasma ADMA were 0.43 ± 0.06μmol/L. Higher level of ADMA was significantly and positively associated with proportion of current smoking. It was also significantly and positively associated with eGFR. In full adjusted linear regression models, ADMA was non-significantly associated with IMT and CCS.
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| Free Research Field |
循環器疫学
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