The relationships of lifestyle factors with the risk of developing gastric cancer in a general Japanese population; the Hisayama Study

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyushu University
• Principal Investigator: IKEDA Fumie 九州大学, 医学(系)研究科(研究院), 助教 (80596825)
• Co-Investigator(Kenkyū-buntansha): 清原 裕 九州大学, 大学院医学研究院環境 医学分野, 教授 (80161602)
• Project Period (FY): 2011 – 2013
• Keywords: 疫学 / 胃癌 / コホート研究

Research Abstract

The aims of this study were to investigate the relationships of lifestyle factors with the risk of developing gastric cancer in a prospective study of 2,742 community-dwelling Japanese individuals aged 40 years or older. First, we investigated the relationship between white blood cell (WBC) count and the development of gastric cancer. As a result, the risk of the cancer increased significantly with higher WBC level. Next, we examined the relationship between dietary vitamin A intake and the risk of gastric cancer. The age- and sex-adjusted incidence of gastric cancer rose linearly with increasing levels of dietary vitamin A intake. Finally, we assessed whether the combination of Helicobacter (H.) pylori serology and serum pepsinogen test could be a good predictor of gastric cancer incidence. As a result, this method significantly increased the predictive ability for gastric cancer, compared with H.pylori serology alone.

Research Products

• [Journal Article] Trends in the incidence and survival of intracerebral hemorrhage by its location in Japanese community (2014)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circ J Volume: 78 Pages: 403-409
• [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population : the Hisayama Study (2014)
  • Author(s): Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 233 Pages: 343-348
• [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects : the Hisayama Study (2014)
  • Author(s): Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y
  • Journal Title: Cardiovac Diabetol Volume: 13 Pages: 45
• [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population : the Hisayama Study (2013)
  • Author(s): Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y
  • Journal Title: Stroke Volume: 44 Pages: 1512-1517
• [Journal Article] Temporal trends in sudden unexpected death in a general population : the Hisayama Study (2013)
  • Author(s): Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y
  • Journal Title: Am Heart J Volume: 165 Pages: 932-938
• [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese : half-century data from the Hisayama Study(1961-2009) (2013)
  • Author(s): Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circulation Volume: 128 Pages: 1198-1205
• [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population : the Hisayama Study (2013)
  • Author(s): Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y
  • Journal Title: Cardiovasc Diabetol Volume: 12 Pages: 164
• [Journal Article] White blood cell count and risk of gastric cancer incidence in a general Japanese population : the Hisayama Study (2012)
  • Author(s): Iida M, Ikeda F, Ninomiya T, Yonemoto K, Doi Y, Hata J, Matsumoto T, Iida M, Kiyohara Y
  • Journal Title: Am J Epidemiol Volume: 175 Pages: 504-510
• [Journal Article] Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population : the Hisayama Study (2012)
  • Author(s): Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y
  • Journal Title: Gastric Cancer Volume: 15 Pages: 162-169
• [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study (2012)
  • Author(s): Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y
  • Journal Title: Scand J Gastroenterol Volume: 47 Pages: 669-675
• [Journal Article] Smoking cessation improves mortality in Japanese men : the Hisayama Study (2012)
  • Author(s): Ikeda F, Ninomiya T, Doi Y, Hata J, Fukuhara M, Matsumoto T, Kiyohara Y
  • Journal Title: Tob control Volume: 21 Pages: 416-421
• [Journal Article] Prevalence and causes of functional disability in an elderly general population of Japanese : the Hisayama Study (2012)
  • Author(s): Yoshida D, Ninomiya T, Doi Y, Hata J, Fukuhara M, Ikeda F, Mukai N, Kiyohara Y
  • Journal Title: J Epidemiol Volume: 22 Pages: 222-229
• [Journal Article] Body mass index and stroke incidence in a Japanese community : the Hisayama Study (2011)
  • Author(s): Yonemoto K, Doi Y, Hata J, Ninomiya T, Fukuhara M, Ikeda F, Mukai N Iida M, Kiyohara Y
  • Journal Title: Hypertens Res Volume: 34 Pages: 274-279
• [Journal Article] Combined effects of smoking and hypercholesterolemia on the stroke and coronary heart disease in Japanese : the Hisayama Study (2011)
  • Author(s): Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y
  • Journal Title: Cerebrovasc Dis Volume: 31 Pages: 477-484
• [Journal Article] N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community : the Hisayama Study (2011)
  • Author(s): Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Ikeda F, Fukuhara M, Iwase M, Kiyohara Y
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Pages: 2997-3003
• [Presentation] 胃癌の疫学調査・久山町研究～H.pylori感染・糖尿病と胃癌の関係を中心に～ (2013)
  • Author(s): 池田文恵
  • Organizer: 第51回日本消化器がん検診学会大会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-09
• [Presentation] 日本人における胃癌発症予測モデルの作成:久山町研究 (2011)
  • Author(s): 飯田真大, 池田文恵, 志方健太郎, 二宮利治, 松本主之, 清原裕
  • Organizer: 第53回日本消化器病学会大会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-10-20