Impact of cardiovascular risk factors on medical expenditures: the Iwate KENCO study

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590810
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Iwate Medical University
• Principal Investigator: TANNO KOZO 岩手医科大学, 医学部, 准教授 (20327026)
• Co-Investigator(Renkei-kenkyūsha): OHSAWA Masaki 岩手医科大学, 医学部, 講師 (60295970) ; ONODA Toshiyuki 岩手医科大学, 医学部, 准教授 (00254748) ; SAKATA Kiyomi 岩手医科大学, 医学部, 教授 (50225794) ; ITAI Kazuyoshi 公益財団法人結核予防会, 第一健康相談 所, 上級研究員 (10048572) ; OKAYAMA Akira 公益財団法人結核予防会, 第一健康相談 所, 所長 (60169159)
• Project Period (FY): 2011 – 2013
• Keywords: 社会医学 / 循環器・高血圧 / コホート / 医療費

Research Abstract

We evaluated the relationship between cardiovascular risk factors (obesity, hypertension, diabetes, dyslipidemia, smoking, and chronic kidney disease (CKD)) and medical expenditures using data of 10899 Japanese National Health Insurance beneficiaries aged less than 75 years (mean, 58.7 years). Mean medical expenditure was higher in participants who had cardiovascular risk factors than those had no risk factor. In this cohort, 12.9% and 6.4% of total medical expenditures were attributable to participants who had hypertension and CKD, respectively.

Research Products

• [Journal Article] Associations of number of teeth with risks for all-cause mortality and cause-specific mortality in middle-aged and elderly men in the northern part of Japan : the Iwate-KENCO study (2014)
  • Author(s): Ando A, Tanno K, Ohsawa M, Onoda T, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ishibashi Y, Kuribayashi T, Koyama T, Itai K, Ogawa A, Okayama A
  • Journal Title: Community Dent Oral Epidemiol
  • DOI: 10.1111/cdoe.12095
  • Peer Reviewed
• [Journal Article] Cardiovascular risk stratification with plasma B-type natriuretic peptide levels in a community-based hypertensive cohort (2014)
  • Author(s): Sato K, Segawa T, Tanaka F, Takahashi T, Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Omama S, Ogasawara K, Ishibashi Y, Makita S, Okayama A, Nakamura M
  • Journal Title: Am J Cardiol Volume: 113 Pages: 682-6
  • DOI: 10.1016/j.amjcard.2013.11.012
  • Peer Reviewed
• [Journal Article] Plasma B-type natriuretic peptide as a predictor of cardiovascular events in subjects with atrial fibrillation : a community-based study (2013)
  • Author(s): Nakamura M, Koeda Y, Tanaka F, Onoda T, Itai K, Ohsawa M, Tanno K, Sakata K, Omama S, Ishibashi Y, Makita S, Ohta M, Ogasawara K, Komatsu T, Okayama A
  • Journal Title: PLoS One Volume: 8 Pages: e81243
  • DOI: 10.1371/journal.pone.0081243.eCollection2013
  • Peer Reviewed
• [Journal Article] High risks of all-cause and cardiovascular deaths in apparently healthy middle-aged people with preserved glomerular filtration rate and albuminuria : A prospective cohort study (2013)
  • Author(s): Ohsawa M, Fujioka T, Ogasawara K, Tanno K, Okamura T, Turin TC, Itai K, Ogawa A, Yoshida Y, Omama S, Onoda T, Nakamura M, Makita S, Ishibashi Y, Tanaka F, Kuribayashi T, Ohta M, Sakata K, Okayama A
  • Journal Title: Int J Cardiol Volume: 170 Pages: 167-72
  • DOI: 10.1016/j.ijcard.2013.10.076
  • Peer Reviewed
• [Journal Article] Predictive value of lipoprotein indices for residual risk of acute myocardial infarction and sudden death in men with low-density lipoprotein cholesterol levels <120 mg/dl (2013)
  • Author(s): Tanaka F, Makita S, Onoda T, Tanno K, Ohsawa M, Itai K, Sakata K, Omama S, Yoshida Y, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Okayama A, Nakamura M; Iwate-Kenco Study Group.
  • Journal Title: Am J Cardiol Volume: 112 Pages: 1063-8
  • DOI: 10.1016/j.amjcard.2013.05.049
  • Peer Reviewed
• [Journal Article] Factors related to tooth loss among community-dwelling middle-aged and elderly Japanese men (2013)
  • Author(s): Ando A, Ohsawa M, Yaegashi Y, Sakata K, Tanno K, Onoda T, Itai K, Tanaka F, Makita S, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, Okayama A
  • Journal Title: J Epidemiol Volume: 23 Pages: 301-6
  • Peer Reviewed
• [Journal Article] Comparison of predictability of future cardiovascular events between chronic kidney disease (CKD) stage based on CKD epidemiology collaboration equation and that based on modification of diet in renal disease equation in the Japanese general population--Iwate KENCO Study (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Turin TC, Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y, Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, Okayama A
  • Journal Title: Circ J Volume: 77 Pages: 1315-25
  • Peer Reviewed
• [Journal Article] Associations of marital status with mortality from all causes and mortality from cardiovascular disease in Japanese haemodialysis patients (2013)
  • Author(s): Tanno K, Ohsawa M, Itai K, Kato K, Turin TC, Onoda T, Sakata K, Okayama A, Fujioka T
  • Journal Title: Nephrol Dial Transplant Volume: 28 Pages: 1013-20
  • DOI: 10.1093/ndt/gfs547
  • Peer Reviewed
• [Journal Article] Concordance of CKD stages in estimation by the CKD-EPI equation and estimation by the MDRD equation in the Japanese general population : the Iwate KENCO Study (2013)
  • Author(s): Ohsawa M, Tanno K, Itai K, Turin TC, Okamura T, Ogawa A, Ogasawara K, Fujioka T, Onoda T, Yoshida Y, Omama S, Ishibashi Y, Nakamura M, Makita S, Tanaka F, Kuribayashi T, Koyama T, Sakata K, Okayama A
  • Journal Title: Int J Cardiol Volume: 165 Pages: 377-9
  • DOI: 10.1016/j.ijcard.2012.08.025
  • Peer Reviewed
• [Journal Article] Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population (2012)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Tanaka F, Makita S, Nakamura M, Omama S, Ogasawara K, Ogawa A, Ishibashi Y, Kuribayashi T, Koyama T, Okayama A
  • Journal Title: J Psychosom Res Volume: 73 Pages: 225-31
  • DOI: 10.1016/j.jpsychores.2012.05.013
  • Peer Reviewed
• [Journal Article] Influence of mild-to-moderate alcohol consumption on cardiovascular diseases in men from the general population (2012)
  • Author(s): Makita S, Onoda T, Ohsawa M, Tanaka F, Segawa T, Takahashi T, Satoh K, Itai K, Tanno K, Sakata K, Omama S, Yoshida Y, Ishibashi Y, Koyama T, Kuribayashi T, Ogasawara K, Ogawa A, Okayama A, Nakamura M
  • Journal Title: Atherosclerosis Volume: 224 Pages: 222-7
  • DOI: 10.1016/j.atherosclerosis.2012.07.004
  • Peer Reviewed
• [Journal Article] Plasma B-type natriuretic peptide is useful for cardiovascular risk assessment in community-based diabetes subjects : comparison with albuminuria (2012)
  • Author(s): Onodera M, Nakamura M, Tanaka F, Takahashi T, Makita S, Ishisone T, Ishibashi Y, Itai K, Onoda T, Ohsawa M, Tanno K, Sakata K, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Sakamaki K, Okayama A
  • Journal Title: Int Heart J Volume: 53 Pages: 176-81
  • Peer Reviewed
• [Journal Article] Sex-specific threshold levels of plasma B-type natriuretic peptide for prediction of cardiovascular event risk in a Japanese population initially free of cardiovascular disease (2011)
  • Author(s): Nakamura M, Tanaka F, Takahashi T, Makita S, Ishisone T, Onodera M, Ishibashi Y, Itai K, Onoda T, Ohsawa M, Tanno K, Sakata K, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Okayama A
  • Journal Title: Am J Cardiol Volume: 108 Pages: 1564-9
  • DOI: 10.1016/j.amjcard.2011.07.011
  • Peer Reviewed
• [Journal Article] Serum C-reactive protein levels and death and cardiovascular events in mild to moderate chronic kidney disease (2011)
  • Author(s): Koeda Y, Nakamura M, Tanaka F, Onoda T, Itai K, Tanno K, Ohsawa M, Makita S, Ishibashi Y, Koyama T, Yoshida Y, Omama S, Ogasawara K, Ogawa A, Kuribayashi T, Okayama A
  • Journal Title: Int Heart J Volume: 52 Pages: 180-4
  • Peer Reviewed
• [Presentation] Low-normal serum albumin levels are significantly associated with an increased risk for incident cardiovascular disease among elderly Japanese people (2013)
  • Author(s): Tanno K, Ohsawa M, Itai K, Onoda T, Ogawa A, Ogasawara K, Nakamura M, Sakata K, Makita S, Omama S, Tanaka F, Ishibashi Y, Okayama A
  • Organizer: 81th European Atherosclerosis Society Congress
  • Place of Presentation: Lyon France
  • Year and Date: 20130603-05
• [Presentation] Associations between serum albumin levels and risks for all-cause mortality and cause-specific mortality in an elderly Japanese community-dwelling population (2013)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Sakata K,Tanaka F,Makita S,Nakamura M,Ishibashi T, Omama S, Ogasawara K,Kuribayashi T, Okayama A
  • Organizer: 52th Cardiovascular Disease Epidemiology and Prevention Annual Conference 2013
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2013-03-19
• [Presentation] 慢性腎臓病と医療費との関連:岩手県北地域コホート研究 (2013)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 坂田清美, 栗林徹, 田中文隆, 蒔田真司, 中村元行, 石橋靖宏, 大間々真一, 小笠原邦昭, 板井一好, 岡山明
  • Organizer: 第23回日本疫学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2013-01-25
• [Presentation] 高齢者の貧血が死亡や介護認定に及ぼす影響:岩手県北地域コホート研究 (2012)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 坂田清美, 栗林徹, 田中文隆, 蒔田真司, 中村元行, 石橋靖宏, 大間々真一, 小笠原邦昭, 板井一好, 岡山明
  • Organizer: 第71回日本公衆衛生学会総会
  • Place of Presentation: 山口市
  • Year and Date: 20121000
• [Presentation] 死亡小票に基づく死因決定と死因別死亡の内訳:岩手県北地域コホート研究の平均5.6年の追跡結果から (2012)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 板井一好, 坂田清美, 田中文隆, 蒔田真司, 中村元行, 石橋靖宏, 大間々真一, 小笠原邦昭, 小川彰, 栗林徹, 岡山明
  • Organizer: 第48回日本循環器病予防学会・日本循環器管理研究協議会総会.
  • Place of Presentation: 東京都
  • Year and Date: 20120600
• [Presentation] Impact of chronic kidney disease on medical expenditures : a 5-year follow-up study of Japanese community dwelling people (2012)
  • Author(s): Tanno K, Ohsawa M, Onoda T, Itai K, Sakata K, Nakamura M, Ogasawara K, Fujioka T, Okayama A
  • Organizer: 80th European Atherosclerosis Society Congress
  • Place of Presentation: Milan, Italy
  • Year and Date: 20120525-28
• [Presentation] 高齢者のbody mass indexと循環器疾患発症リスクとの関連:岩手県北地域コホート研究 (2012)
  • Author(s): 丹野高三, 栗林徹, 大澤正樹, 小野田敏行, 板井一好, 坂田清美, 田中文隆, 蒔田真司, 中村元行, 大間々真一, 小笠原邦昭, 小川彰, 石橋靖宏, 小山富子, 岡山明
  • Organizer: 第22回日本疫学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 20120100
• [Presentation] Body mass index and stroke incidence in Japanese elderly men (2012)
  • Author(s): Tanno K, Ohsawa M, Itai K, Onoda T, Ogawa A, Ogasawara K, Nakamura M, Sakata K, Makita S, Omama S, Tanaka F, Ishibashi Y, Okayama A
  • Organizer: 51th Cardiovascular Disease Epidemiology and Prevention Annual Conference 2012
  • Place of Presentation: San Diego, CA
  • Year and Date: 2012-03-14
• [Presentation] 循環器疾患危険因子の集積状況が医療費支出に与える影響 (2011)
  • Author(s): 丹野高三, 大澤正樹, 小野田敏行, 板井一好, 坂田清美, 岡山明
  • Organizer: 第70回日本公衆衛生学会総会
  • Place of Presentation: 秋田市
  • Year and Date: 20111000
• [Presentation] Can the direct homogenous low-density lipoprotein cholesterol assay be used in epidemiological studies? (2011)
  • Author(s): Tanno K, Okamura T, Ohsawa M, Nakamura M, Sakata K
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌市
  • Year and Date: 20110700