2013 Fiscal Year Final Research Report
A longitudinal study on the relation between overall sleep status and subsequent changes in serum high-sensitivity C-reactive protein
| Project/Area Number |
23590817
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156)
SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 睡眠 / 炎症 / 縦断研究 |
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| Research Abstract |
We investigated the relation between overall sleep status based on the global score of a partially-modified version of Pittsburgh Sleep Quality Index (PSQI) and subsequent changes in serum high-sensitivity C-reactive protein (hsCRP) in 991 middle-aged Japanese factory workers without increased and potentially pathogenic levels of inflammation (hsCRP at year 3 >= 1.0 mg/L). The subsequent changes in hsCRP after 3 years were grater in subjects with unfavorable sleep habits, defined as a PSQI global score > 5.5 points, compared with those with a normal pattern. The geometric means of hsCRP at year 3 were 0.275 mg/L and 0.242 mg/L, respectively, after adjusting for baseline hsCRP and other potential confounders (p=0.04). The multivariate-adjusted odds ratio for developing that inflammation due to unfavorable sleep was 2.08 (1.29-3.35). Unfavorable sleep is associated with activation of low-grade systemic inflammation.
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[Journal Article] Overall sleep status and high sensitivity C-reactive protein : a prospective study in Japanese factory workers
Author(s)
Nakamura K, Sakurai M, Miura K, Morikawa Y, Nagasawa SY, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Nakagawa H
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Journal Title
Journal of Sleep Research
Volume: (in press)
Peer Reviewed
