Chronic kidney disease, thyroid dysfunction and cardiovascular risk

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437) ; YOSHITA Katsushi 大阪市立大学, 生活科学研究科, 教授 (60299245)
• Co-Investigator(Renkei-kenkyūsha): MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156) ; NAKAMURA Koshi 金沢医科大学, 医学部, 准教授 (80422898)
• Project Period (FY): 2011 – 2013
• Keywords: 疫学 / 生活習慣病 / 内分泌学

Research Abstract

This study investigated the association between chronic kidney disease, thyroid dysfunction and cardiovascular risk factors in Japanese men and women.
In a cross-sectional analyses, thyroid stimulating hormone (TSH) were related to the estimated glomerular filtration ratio (eGFR) (r=-0.125, p<0.001), and prevalence of thyroid dysfunction were higher in participants with low eGFR compared to those with normal eGFR.
Changes in TSH levels during a 3-year follow-up were not associated with baseline eGFR. Baseline TSH levels were not associated with a 3-year changes in cardiovascular risk factors such as blood pressure and plasma lipid levels. However, decrease in HDL-cholesterol were significantly higher for participants with hypothyroidism accompanied by renal dysfunction compared to those with normal thyroid/renal function. These results suggest that hypothyroidism accompanied by the renal dysfunction may higher the risk of cardiovascular disease through the decrease in HDL-cholesterol.

Research Products

• [Journal Article] Association between serum thyroid stimulating hormone within the normal range and indices of obesity in Japanese men and women (2014)
  • Author(s): Sakurai M, Nakamura K, Miura K, Yoshita K, Takamura T, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa N, Suwazono Y, Nakagawa H
  • Journal Title: Intern Med Volume: 53 Pages: 669-674
  • Peer Reviewed