2013 Fiscal Year Final Research Report

Chronic kidney disease, thyroid dysfunction and cardiovascular risk

Research Project

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Project/Area Number	23590819
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Public health/Health science
Research Institution	Kanazawa Medical University
Principal Investigator	SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216)
Co-Investigator(Kenkyū-buntansha)	NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437) YOSHITA Katsushi 大阪市立大学, 生活科学研究科, 教授 (60299245)
Co-Investigator(Renkei-kenkyūsha)	MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156) NAKAMURA Koshi 金沢医科大学, 医学部, 准教授 (80422898)
Project Period (FY)	2011 – 2013
Keywords	疫学 / 生活習慣病 / 内分泌学
Research Abstract	This study investigated the association between chronic kidney disease, thyroid dysfunction and cardiovascular risk factors in Japanese men and women. In a cross-sectional analyses, thyroid stimulating hormone (TSH) were related to the estimated glomerular filtration ratio (eGFR) (r=-0.125, p<0.001), and prevalence of thyroid dysfunction were higher in participants with low eGFR compared to those with normal eGFR. Changes in TSH levels during a 3-year follow-up were not associated with baseline eGFR. Baseline TSH levels were not associated with a 3-year changes in cardiovascular risk factors such as blood pressure and plasma lipid levels. However, decrease in HDL-cholesterol were significantly higher for participants with hypothyroidism accompanied by renal dysfunction compared to those with normal thyroid/renal function. These results suggest that hypothyroidism accompanied by the renal dysfunction may higher the risk of cardiovascular disease through the decrease in HDL-cholesterol.

Research Products
(1 results)

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

[Journal Article] Association between serum thyroid stimulating hormone within the normal range and indices of obesity in Japanese men and women2014
- Author(s)
  Sakurai M, Nakamura K, Miura K, Yoshita K, Takamura T, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa N, Suwazono Y, Nakagawa H
- Journal Title
  
  Intern Med
  
  Volume: 53 Pages: 669-674
- Peer Reviewed