2013 Fiscal Year Final Research Report
Development of new risk score of CHD and assement of new biomarkers based on Suita Cohort
| Project/Area Number |
23590835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NISHIMURA Kunihiro 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 室長 (70397834)
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| Project Period (FY) |
2011 – 2013
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| Keywords | リスクスコア / バイオマーカー / コホート研究 |
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| Research Abstract |
Framingham risk score (FRS) is known as one of standard prediction tools for coronary heart disease (CHD) incidence. No previous study investigated its efficacy for Japanese population cohort. The purpose of this study was to make newly developed coronary prediction algorithms for a Japanese population in the manner of FRS compared with original FRS.Our coronary prediction algorithms for Japanese were based on a large population-based cohort study (Suita study). Study subjects comprised initially 5,886 healthy Japanese.
The C-statistics showed the new model is better for accuracy than the original and recalibrated Framingham Scores. The net reclassification improvement (NRI) by the Suita score with inclusion of CKD was 41.2% (P<0.001) compared with the original FRS. Recalibration of FRS slightly improved the efficiency of the prediction, but still worse than the Suita score with CKD model. The Suita score with CKD predicted the risk of CHD more properly.
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[Journal Article] LDL cholesterol performance of beta quantification reference measurement procedure2014
Author(s)
Nakamura M, Kayamori Y, Iso H, Kitamura A, Kiyama M, Koyama I, Nishimura K, Nakai M, Noda H, Dasti M, Vesper HW, Miyamoto Y
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Journal Title
Clin Chim Acta
Volume: 431
Pages: 288-93
Peer Reviewed
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[Journal Article] Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease2014
Author(s)
Haraguchi Y, Toh R, Hasokawa M, Nakajima H, Honjo T, Otsui K, Mori K, Miyamoto-Sasaki M, Shinohara M, Nishimura K, Ishida T, Hirata KI
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Journal Title
Atherosclerosis
Volume: 234(2)
Pages: 288-294
Peer Reviewed
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[Journal Article] Blood Pressure, Low-Density Lipoprotein Cholesterol, and Incidences of Coronary Artery Disease and Ischemic Stroke in Japanese : The Suita Study2014
Author(s)
Tsukinoki R1, Okamura T, Watanabe M, Kokubo Y, Higashiyama A, Nishimura K, Takegami M, Murakami Y, Okayama A, Miyamoto Y.
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Journal Title
Am J Hypertens
Volume: (Epub ahead of print)
Peer Reviewed
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[Journal Article] Do differences in risk factors explain the lower rates of coronary heart disease in Japanese versus U.S. women?2013
Author(s)
Sekikawa A, Willcox BJ, Usui T, Carr JJ, Barinas-Mitchell EJ, Masaki KH, Watanabe M, Tracy RP, Bertolet MH, Evans RW, Nishimura K, Sutton-Tyrrell K, Kuller LH, Miyamoto Y
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Journal Title
Journal of women's health
Volume: 22(11)
Pages: 966-77
Peer Reviewed
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[Journal Article] Treated and untreated hypertension, hospitalization, and medical expenditure : an epidemiological study in 314 622 beneficiaries of the medical insurance system in Japan2013
Author(s)
Nakamura K, Miura K, Nakagawa H, Okamura T, Okuda N, Nishimura K, Yasumura S, Sakata K, Hidaka H, Okayama A
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Journal Title
Journal of hypertension
Volume: 31(5)
Pages: 1032-42
Peer Reviewed
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[Journal Article] Fasting serum concentration of apolipoprotein B48 represents residual risks in patients with new-onset and chronic coronary artery disease. Clinica chimica acta2013
Author(s)
Mori K, Ishida T, Yasuda T, Monguchi T, Sasaki M, Kondo K, Hasokawa M, Nakajima H, Haraguchi Y, Sun L, Shinohara M, Toh R, Nishimura K, Hirata KI
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Journal Title
international journal of clinical chemistry
Volume: 421C
Pages: 51-6
Peer Reviewed
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[Journal Article] 【虚血性疾患の課題と展望】脳卒中急性期治療の課題包括的脳卒中センターの整備に向けて2013
Author(s)
飯原弘二, 西村邦宏, 嘉田晃子, 中川原譲二, 小笠原邦昭, 小野純一, 塩川芳昭, 有賀徹, 宮地茂, 豊田一則, 松田晋哉, 永田泉, 石川ベンジャミン光一, 鈴木明文, 森久恵, 片岡大治, 中村文明, Group J-AS
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Journal Title
脳神経外科ジャーナル
Volume: 22(9)
Pages: 678-87
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[Presentation] Increased Acute Myocardial Infarction Mortality after the Great East Japan Earthquake : An Analysis of Death Certificate Data2014
Author(s)
Misa Takegami, Yoshihiro Miyamoto , Satoshi Yasuda , Kunihiro Nishimura , Motoyuki Nakamura , Yasuchika Takeishi , Kenichi Hirata , Yoshihiro Morino ,Hisao Ogawa , Hiroaki Shimokawa , Hiroaki Naito
Organizer
第78回日本循環器学会学術集会(JCS2014)
Place of Presentation
東京
Year and Date
2014-03-21
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[Presentation] Effects of Organized Stroke Care on In-Hospital Mortality and Morbidity of Patients With Ischemic and Hemorrhagic Stroke : J-ASPECT Study2014
Author(s)
Kunihiro Nishimura, Satoru Kamitani, Michikazu Nakai, Akiko Kada, Fumiaki Nakamura, Hiroharu Kataoka, Yoshihiro Miyamoto, Kuniaki Ogasawara, Junichi Ono, Shigeru Miyachi, Yoshiaki Shiokawa, Shinya Matsuda, Matsuda, Izumi Nagata, Toru Aruga, Suzuki Akifumi, Kazunori Toyoda, Koichi Jyoji, Nakagawara, Koji Iihara
Organizer
ISC2014
Place of Presentation
San diego
Year and Date
2014-03-12
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[Presentation] 高純度EPA製剤の腎保護効果: OKEHAZAMA Trial (Outcomes in chronic Kidney disease by purified Eicosapentaenoic acids for the prevention of HAZardous events : A Multicenter rAndomized control Trial)2014
Author(s)
林宏樹, 多国将士, 浅田瞥明, 久志本浩子, 畢崎子町, 山下浩, 杉山大典, 佐藤和ー, 西村邦宏, 杉山手目覚, 山本幸一郎防, 高橋和男, 小出滋久, 富田亮, 長谷川みどり, 湯津由紀夫
Organizer
第26回腎と脂質研究会
Place of Presentation
愛知
Year and Date
2014-03-08
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[Presentation] 本邦の急性期脳卒中患者36,534人における受療時間帯と30日以内全死因死亡率の関係-J-ASPECT Study-2013
Author(s)
本郷卓, 西村邦宏, 神谷諭, 中川原譲二, 有賀徹, 永田泉, 豊田一則, 松田晋哉, 宮本恵宏, et al
Organizer
第72回日本脳神経外科学会総会
Place of Presentation
パシフィコ横浜
Year and Date
2013-10-16
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