2013 Fiscal Year Final Research Report
Comprehensive analysis for biological toxicity with synthetic narcotic MDMA
| Project/Area Number |
23590845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 合成麻薬 / MDMA / 毒性 / 遺伝子 / 多因子解析 / 覚せい剤 |
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| Research Abstract |
MDMA is a synthetic narcotic, which is resembled to methamphetamine (MA) structure. The aim of this study is clear the differences of biological functions from MDMA and MA. MDMA and MA were separately injected to mice once two days during 51 days as well as saline for a blank experiment. Mice weights for MDMA or MA were decreased to those of a blank group for 10-20 days. Then mice weights for MDMA and MA were increased same rate as the blank group. Comprehensive mRNA analyses with the brain and heart showed changes of metabolic factors for lipids and fatty acids, cytokines, transcription factors, translations factors, and others. These results are fundamental to the next experiment.
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