Relationship between alcoholic liver disorders and sudden death

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590850
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Yamaguchi University
• Principal Investigator: FUJIMIYA Tatsuya 山口大学, 医学(系)研究科(研究院), 教授 (50219044)
• Co-Investigator(Kenkyū-buntansha): LIU Jinyao 山口大学, 大学院医学系研究科, 講師 (60379956) ; HAKUCHO Ayako 山口大学, 大学院医学系研究科, 助教 (90593301)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: アルコール / 肝障害 / 脂肪肝 / 突然死 / 大酒家 / 心筋症 / 法医学 / アルコール医学

Outline of Final Research Achievements

We studied the relationship between alcoholic liver disorders and sudden death. Rats and Mouse were treated with Liber diet which includes alcohol or sugar of the same calories for 6 weeks. Then animals were divided to the control group, sustained alcohol treated group and alcohol withdrawal group for 1day to 3 weeks. The liver and heart were pathologically examined. As a result, the sudden death occurred in the alcohol withdrawal group for 1 day. The liver revealed fat deposits and myofibroblast proliferation. The heart revealed slight fibrosis between myocytes.

Free Research Field

法医学