2014 Fiscal Year Final Research Report
Elucidation of the mechanism of imbalance in dementia patients
Project/Area Number |
23590869
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOGANEZAWA Tadachika 筑波大学, 医学医療系, 助教 (80431691)
TAMAOKA Akira 筑波大学, 医学医療系, 教授 (50192183)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Keywords | アルツハイマー病 / 前庭 / 眼球運動 / visual suppression / 転倒 / バランス / 前庭中枢 / 認知症 |
Outline of Final Research Achievements |
In patients with Alzheimer's disease (AD), we investigated balance impairment from the viewpoint of the vestibular regulation mechanism. To test the equilibrium function, we conducted a caloric nystagmus test. The SR is the suppression rate of vestibular nystagmus during the visual suppression (VS) test. The fact that the SR of patients who have a tendency to fall was significantly lower than in those who do not indicates that the SR is an effective indicator of the tendency to fall in AD patients. Impairment of VS in AD might arise from cerebral vestibular cortex impairment rather than comorbid peripheral vestibular disorders.
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Free Research Field |
神経眼科
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