2013 Fiscal Year Final Research Report
The effects of ghrelin on electrogastrography in anorexia nervosa
| Project/Area Number |
23590872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Graduate Institute for Policy Studies |
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Principal Investigator |
SUZUKI Mari (堀田 眞理) 政策研究大学院大学, 保健管理センター, 教授 (90128140)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経性食欲不振症 / グレリン / 胃電図 / 六君子湯 |
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| Research Abstract |
To develop a possibly new medical treatment for anorexia nervosa, we aimed to investigate the effects of ghrelin on gastric function by using electrogastrography (EGG) as a non-invasive technique. Because Rikkunshito (TJ-43), a traditional Japanese medicine, stimulates ghrelin secretion, we studied the effects of TJ-43 on the gastric electrical activity of patients with anorexia nervosa. The % normal power and % arrhythmia of EGG in patients with anorexia nervosa were significantly lower and higher than those of healthy controls, respectively. Oral administration with 5g TJ-43 resolved in 50ml water significantly decreased % arrhythmia of EGG in patients with anorexia nervosa compared to the 50ml water load. TJ-43 may improve gastric myoelectrical rhythms in patients with anorexia nervosa, suggesting that the effect of ghrelin on appetite would be related to amelioration of gastric myoelectric activity.
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