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2013 Fiscal Year Final Research Report

Detection of novel actions of kampo medicines for lipid metabolism by lipidomic analysis

Research Project

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Project/Area Number 23590873
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of Toyama

Principal Investigator

SHIRO Watanabe  富山大学, 和漢医薬学総合研究所, 准教授 (00222406)

Co-Investigator(Kenkyū-buntansha) TSUNEYAMA Koichi  富山大学, 大学院医学薬学研究部(医学), 准教授 (10293341)
Project Period (FY) 2011 – 2013
Keywords胆汁酸 / トリグリセリド / 一価不飽和脂肪酸 / ステアリン酸CoA不飽和化酵素1
Research Abstract

The administration of Boiogito (BOT) was shown to ameliorate liver injury in the mice fed a cholate (CA)-supplemenetd diet. This effect was associated with a partial restoration of the reduction in liver triglyceride (TG) content. The levels of gene and protein of stearoyl-CoA desaturase-1 (SCD1) were lowered in the mice fed the CA-supplemented diet, which were elevated by BOT administration. These results suggest that the amelioration of CA-induced liver injury by BOT administration may be due to the restoration of reduced synthesis of liver TG through the facilitation of desaturation of saturated fatty acids, which is required in the efficient TG synthesis in liver. Alternatively, the reduction in liver TG levels might be a consequence of the amelioration of CA-induced liver injury by BOT administration. Thus, our lipidomic analysis revealed a novel mechanism involved in the modulation of lipid metabolism by a kampo medicine during bile acid-induced steatohepatitis in the mice.

  • Research Products

    (20 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (15 results)

  • [Journal Article] Pig bile reduces hepatic triglyceride content in mice2013

    • Author(s)
      Watanabe S., Fujita K.
    • Journal Title

      J. Trad. Med.

      Volume: 30 Pages: 190-197

    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet2013

    • Author(s)
      Watanabe S., Tsuneyama K.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 38 Pages: 379-390

    • Peer Reviewed
  • [Journal Article] Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice : mediation by cholic acid2012

    • Author(s)
      Watanabe S., Tsuneyama K.
    • Journal Title

      J. Toxicol. Sci.

      Volume: 37 Pages: 105-121

    • Peer Reviewed
  • [Journal Article] Cattle bile aggravates diclofenac sodium-induced small intestinal injury in mice2011

    • Author(s)
      Ishikawa H., Watanabe S.
    • Journal Title

      Evid. Based. Complement. Alternat. Med.

    • DOI

      10.1155/2011/315858

    • Peer Reviewed
  • [Journal Article] Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage

    • Author(s)
      Yamawaki H., Mihara H., Suzuki N., Nishizono H., Uchida K., Watanabe S., Tominaga M., Sugiyama T.
    • Journal Title

      Am. J. Physiol. Gastrointest. Liver Physiol.

    • DOI

      10.1152/ajpgi.00105.2013

    • Peer Reviewed
  • [Presentation] ケイヒのLC-MSによる網羅的成分分析と産地特有のマーカー化合物の同定2013

    • Author(s)
      田中謙、李峰、渡辺志朗、川原信夫
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Year and Date
      20130831-0901
  • [Presentation] Exogenous/endogenous substances detected in the plasma and brain after chitosan treatment in mice2013

    • Author(s)
      牛一民、稲田千香子、趙キ、李峰、渡辺志朗、岡淳一郎、松本欣三
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Year and Date
      20130831-0901
  • [Presentation] 加味四物湯のサルコペニア(筋肉減少症)改善作用の検討(2)2013

    • Author(s)
      田邊宏樹、水野弘樹、井上未央里、森智一、中島健一、渡辺志朗、林忠紘、中島賢治、和田篤敬、井上誠
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Year and Date
      20130831-0901
  • [Presentation] A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching-LC/MS/MS2012

    • Author(s)
      渡辺健一,石川千裕,桑原弘,佐藤公彦,小室勢津子,中川徹也,野村成章,矢吹昌司,渡辺志朗
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Year and Date
      20121120-22
  • [Presentation] Eicosapentenoic acid supplementation attenuates hepatic accumulation of cholesterol esters but aggravates liver injury in mice fed a fat- and sodium cholate-supplemented diet in mice2012

    • Author(s)
      Shiro Watanabe
    • Organizer
      The 1st International Conference on Pharma and Food
    • Place of Presentation
      Shizuoka
    • Year and Date
      20121115-16
  • [Presentation] Phytochemical study on the root of Dipsacus asper, a Kampo medicine2012

    • Author(s)
      李峰、渡辺志朗、手塚康弘、田中謙
    • Organizer
      日本生薬学会第59回年会
    • Place of Presentation
      千葉
    • Year and Date
      20120917-18
  • [Presentation] コール酸/高脂肪添加食によって誘導される脂肪性肝炎様症状に及ぼすエイコサペンタエン酸の影響2012

    • Author(s)
      渡辺志朗
    • Organizer
      日本脂質栄養学会第21回大会
    • Place of Presentation
      麻布
    • Year and Date
      20120907-08
  • [Presentation] 胆汁酸添加高脂肪食によって誘導される脂肪性肝炎様症状に及ぼすエイコサペンタエン酸の影響2012

    • Author(s)
      渡辺志朗
    • Organizer
      胆汁酸研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-12-01
  • [Presentation] 豚胆の脂質低下作用2012

    • Author(s)
      渡辺志朗、李峰、米山惇志、湖間戸俊輔
    • Organizer
      第29回和漢医薬学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-12
  • [Presentation] エイコサペンタエン酸がコール酸添加高脂肪食により誘導される脂肪性肝炎様症状に及ぼす影響2011

    • Author(s)
      渡辺志朗、吉田康彦、湖間戸俊輔、浜田雄大、常山幸一
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      20110921-24
  • [Presentation] トランス脂肪酸は脂肪細胞のインスリン応答性を低下させる2011

    • Author(s)
      大嶋利之、澤田啓介、根橋佳奈、大蔵直樹、渡辺志朗、厚味厳一
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      20110921-24
  • [Presentation] 牛胆は一価不飽和脂肪酸含有コレステロールエステルの優位な蓄積を伴う脂肪肝を誘導する2011

    • Author(s)
      渡辺志朗,常山幸一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      20110328-31
  • [Presentation] 脂肪細胞でのトランス脂肪酸によるインスリン抵抗性に関する解析2011

    • Author(s)
      澤田啓介,根橋佳奈,大藏直樹,渡辺志朗,厚味厳一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      20110328-31
  • [Presentation] 牛胆によって誘導される脂質代謝変化と脂肪性肝炎様症状における胆汁酸の役割2011

    • Author(s)
      渡辺志朗
    • Organizer
      第33回胆汁酸研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-17
  • [Presentation] 牛胆の投与によって誘導される脂肪性肝炎様症状に伴う脂質代謝変化の解析2011

    • Author(s)
      渡辺志朗
    • Organizer
      第12回Pharmaco-hematology Symposium
    • Place of Presentation
      富山
    • Year and Date
      2011-06-20

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Published: 2015-07-16  

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