2013 Fiscal Year Final Research Report
Cross link between diabetes mellitus and bone metabolism in the aspect of renin angiotensin system
| Project/Area Number |
23590879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka University |
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Principal Investigator |
SHIMIZU Hideo 大阪大学, 医学(系)研究科(研究院), 特任准教授 (50388378)
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| Co-Investigator(Kenkyū-buntansha) |
RAKUGI Hiromi 大阪大学, 大学院医学系研究科・老年腎臓内科, 教授 (20252679)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨代謝 / 糖尿病 / レニン / アンジオテンシン / 降圧薬 |
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| Research Abstract |
10 weeks-old rats were ovariectomised and fed with high-fructose diet for 1M to develop type 2 diabetes mellitus. These animals demonstrated high turnover in bone metabolisms, glucose- and insulin- tolerance accompanying activation of renin angiotensin system. They also revealed accumulation of advanced glycation-endo products with fragility of bone assessed by 3-ponit vending test. Angiotensin type 1 receptor blockers ameliorated these parameters with its beneficial pleiotropic effects.
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