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2013 Fiscal Year Final Research Report

Objective evaluation of the effect that malnutrition of anorexia nervosa causes to cerebral, digestion , metabolic function

Research Project

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Project/Area Number 23590884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionKyushu University

Principal Investigator

KAWAI KEISUKE  九州大学, 大学病院, 講師 (80325521)

Co-Investigator(Kenkyū-buntansha) KUBO Chiharu  九州大学病院, 院長 (80117100)
YOSHIURA Takashi  九州大学病院, 放射線科, 准教授 (40322747)
Co-Investigator(Renkei-kenkyūsha) TOBIMATSU Shozo  九州大学, 体情報科学講座脳神経生理学, 教授 (40164008)
Project Period (FY) 2011 – 2013
Keywords神経性食欲不振症 / 低栄養状態 / 脳機能検査 / 脳波 / 体組成
Research Abstract

We made the score table which assessed electroencephalographic(EEG) data of the anorexia nervosa (AN) using Fourier transfer objectively.Using fMRI study at the closed eyes rest, we proved that the activity changes in posterior cingulatecortex (PCC) and medial prefrontal cortex (MPFC) during nutrition therapy in the AN. This may catch a characteristic of AN developing for overeating at relax.
For anorexia nervosa (AN), in the case of an malnutrition state with Body mass index (BMI) 12kg/m2 or less, the energy supply at starvation shifts from fat store to the catabolism of the muscle and internal organs tissue. This state leads to a physical crisis.

  • Research Products

    (18 results)

All 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Book (2 results) Remarks (1 results)

  • [Journal Article] 摂食障害治療最近の工夫-身体面の治療と心理療法について2013

    • Author(s)
      河合啓介
    • Journal Title

      心身医学

      Volume: 第53巻 Pages: 834-840

  • [Journal Article] 行動制限を用いた認知行動療法2013

    • Author(s)
      河合啓介
    • Journal Title

      臨床精神医学

      Volume: 第42巻第5号 Pages: 621-626

  • [Journal Article] The outcome of Japanese anorexia nervosa patients treated with an inpatient therapy in an internal medicine unit2012

    • Author(s)
      N. Amemiya, M. Takii , T. Hata, C. Morita , S. Takakura , K. Oshikiri, H. Urabe, S.Tokunaga, T.Nozaki, K.Kawai, N. Sudo,and C. Kubo
    • Journal Title

      Eat.Weight Disord

      Volume: 17 Pages: e1-8

    • Peer Reviewed
  • [Journal Article] Daily physical complaints and hippocampal function : An fMRI study of pain modulation by anxiety2012

    • Author(s)
      M Gondo, Y Morigichi , N Kodama, N Sato, N Sudo C Kubo, G Komaki
    • Journal Title

      Neuroimage

    • Peer Reviewed
  • [Journal Article] 神経性食欲不振症のバイオマーカー, 第52回日本心身医学会総会ならびに学術総会シンポジウム:摂食障害の新たな展開2012

    • Author(s)
      河合啓介、山下さきの、久保千春、瀧井正人、須藤信行
    • Journal Title

      心身医学

      Volume: vol 52, No,3 Pages: 201-207

  • [Journal Article] 身体的心理的摂食調節機構に基づく肥満治療, 第52回日本心身医学会総会ならびに学術総会シンポジウム:生活習慣病の心身医学-生活習慣病のターゲット、肥満介入の光と影2012

    • Author(s)
      河合啓介、久保千春、森田千尋、松原慎、高倉修、瀧井正人、野崎剛弘、須藤信行
    • Journal Title

      心身医学

      Volume: vol 52, No,10 Pages: 911-917

  • [Journal Article] 摂食障害の神経内分泌・代謝に関する研究2012

    • Author(s)
      河合啓介
    • Journal Title

      医学のあゆみ

      Volume: vol 241 No.9 Pages: 649-654

  • [Journal Article] 摂食調節物質からみた心理行動科学的アプローチ特集, 糖尿病患者のこころとからだ-心理行動科学的アプローチによる治療戦略2012

    • Author(s)
      河合啓介
    • Journal Title

      月刊糖尿病

      Volume: vol.4 No.4 Pages: 65-469

  • [Journal Article] The longitudinal BMI pattern and body composition of patients with anorexia nervosa who require urgent hospitalization : A case control study2011

    • Author(s)
      K Kawai, S Yamashita, T Yamanaka, M Gondo, C Morita, T Nozaki, S Takakura, T Hata, Y Yamada, S Matubayashi, M Takii, C Kubo, N Sudo
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 5 Pages: 14

    • Peer Reviewed
  • [Journal Article] 神経性食欲不振症の栄養管理の注意点2011

    • Author(s)
      河合啓介、山下さきの
    • Journal Title

      臨床栄養

      Volume: 119 Pages: 29-33

  • [Presentation] Ghrelin activation in response to medium chain fatty acid administration in patients with Anorexia nervosa2013

    • Author(s)
      K Kawai, M Nakashima, S Takakura, M Takii, C Kubo, N Sudo
    • Organizer
      The 22^<st> World Congress on Psychosomatic Medicine
    • Place of Presentation
      Lisbon Portugal (25-28)
    • Year and Date
      20130912-15
  • [Presentation] 摂食障害治療の最近の進歩-エネルギー代謝の側面から2012

    • Author(s)
      河合啓介
    • Organizer
      第17回日本心療内科学会総会・学術大会
    • Place of Presentation
      福岡
    • Year and Date
      20121117-18
  • [Presentation] Recent progress in the treatment of eating disorders from the viewpoint of energy metabolism2012

    • Author(s)
      Keisuke Kawai
    • Organizer
      The 15 congress of the asian college of psychosomatic medicine
    • Place of Presentation
      Ulaanbaatar , Mongol
    • Year and Date
      20120823-25
  • [Presentation] 神経性食欲不振症患者における低栄養からの回復過程での、基礎代謝・体組成・摂食関連ペプチドの変動2012

    • Author(s)
      河合啓介,山下さきの,高倉修,瀧井正人,野崎剛弘,久保千春,須藤信行
    • Organizer
      第52回日本心身医学会総会ならびに学術総会
    • Place of Presentation
      鹿児島
    • Year and Date
      20120525-26
  • [Presentation] The change of somatic parameters in the recovery process from malnutrition state in anorexia nervosa2011

    • Author(s)
      K Kawai, S Yamashita, M Takii, T Nozaki, S Takakura, C Kubo, N Sudo
    • Organizer
      The 21^<st> World Congress on Psychosomatic Medicine
    • Place of Presentation
      Korea
    • Year and Date
      20110825-28
  • [Book] 摂食障害治療ガイドライン, 日本摂食障害学会監修2012

    • Author(s)
      河合啓介
    • Total Pages
      166-170
    • Publisher
      医学書院
  • [Book] 薬局増刊号病気と薬パーフェクトBOOK2011, 神経性食欲不振症2011

    • Author(s)
      河合啓介(分担)
    • Total Pages
      1083-1085
    • Publisher
      南山堂
  • [Remarks]

    • URL

      http://www.cephal.med.kyushu-u.ac.jp/

URL: 

Published: 2015-07-16  

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