2013 Fiscal Year Final Research Report
Establishment of new strategy for preventing the prothrombotic tendency of metabolic syndrome
| Project/Area Number |
23590905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
HIROKO Tsuda 中村学園大学, 栄養科学部, 教授 (30180003)
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| Project Period (FY) |
2011 – 2013
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| Keywords | メタボリックシンドローム / 向血栓症 / プロテインS / プロテインC / ApoCII |
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| Research Abstract |
Protein S (PS) is an anticoagulant factor that plays an important role in the protein C (PC) anticoagulant pathway, and its dysfunction is a main thrombophilia among Japanese. The clinical studies on obese women and young adult women uncovered that total PS mass concentration in plasma is positively correlated with the amounts of PC and ApoCII. The PS mRNA expression in HepG2 cells, a human hepatoma cell line, is decreased by adding resveratrol, a polyphenol present in wine, and by lowering the glucose concentration in culture medium. These results suggest that PS in plasma may bind with lipoproteins, such as VLDL and IDL, and protect the prothrombotic tendency of metabolic syndrome.
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