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2013 Fiscal Year Final Research Report

Establishment of new strategy for preventing the prothrombotic tendency of metabolic syndrome

Research Project

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Project/Area Number 23590905
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNakamura Gakuen College

Principal Investigator

HIROKO Tsuda  中村学園大学, 栄養科学部, 教授 (30180003)

Project Period (FY) 2011 – 2013
Keywordsメタボリックシンドローム / 向血栓症 / プロテインS / プロテインC / ApoCII
Research Abstract

Protein S (PS) is an anticoagulant factor that plays an important role in the protein C (PC) anticoagulant pathway, and its dysfunction is a main thrombophilia among Japanese. The clinical studies on obese women and young adult women uncovered that total PS mass concentration in plasma is positively correlated with the amounts of PC and ApoCII. The PS mRNA expression in HepG2 cells, a human hepatoma cell line, is decreased by adding resveratrol, a polyphenol present in wine, and by lowering the glucose concentration in culture medium. These results suggest that PS in plasma may bind with lipoproteins, such as VLDL and IDL, and protect the prothrombotic tendency of metabolic syndrome.

  • Research Products

    (33 results)

All 2014 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 5 results) Presentation (21 results) (of which Invited: 8 results) Book (3 results)

  • [Journal Article] Discontinuation of leisure time impact-loading exercise is related to reduction of a calcaneus quantitative ultrasound parameter in young adult Japanese females : a 3-year follow-up study2014

    • Author(s)
      Nakazono E., Miyazaki H., Abe S., Imai K., Tsuda H. (責任著者),その他8名
    • Journal Title

      Osteoporos Int.

      Volume: 25 (2) Pages: 485-495

    • DOI

      10.1007/s00198-013-2416-4

    • Peer Reviewed
  • [Journal Article] High protein intake is associated with low prevalence of frailty among old Japanese women : a multicenter cross-sectional study2013

    • Author(s)
      Kobayashi S., Asakura K., Suga H., Sasaki S. and the Three-generation Study of Women on Diets and Health Study Group
    • Journal Title

      Nutr. J

      Volume: 12 Pages: 164

    • DOI

      10.1186/1475-2891-12-164

    • Peer Reviewed
  • [Journal Article] Activated protein C anticoagulant system dysfunction and thrombophilia in Asia2013

    • Author(s)
      Hamasaki N, Kuma H, Tsuda H.
    • Journal Title

      Ann. Lab. Med

      Volume: 33(1) Pages: 8-13

    • DOI

      10.3343/alm.2013.33.1.8

    • Peer Reviewed
  • [Journal Article] ResveratrolのHepG2細胞でのplasminogen activator inhibitor-1発現に与える影響2013

    • Author(s)
      宮崎(廣戸)美絵、津田博子、石橋源次
    • Journal Title

      九州共立大学総合研究所紀要

      Volume: 6 Pages: 11-14

    • URL

      http://www3.kyukyo-u.ac.jp/K0001/kiyou_r6.html

  • [Journal Article] アジア人特有の血栓性素因-プロテインS異常症-2012

    • Author(s)
      津田博子、津田友秀
    • Journal Title

      日本血栓止血学会誌

      Volume: 23 (4) Pages: 379-382

    • URL

      http://www.jsth.org/publications/index.html

  • [Journal Article] 寝たきり要介護高齢者における体重推定式の作成2012

    • Author(s)
      大西玲子、藤井弘二、津田博子、今井克己
    • Journal Title

      日本老年医学会雑誌

      Volume: 49 (6) Pages: 749-751

    • URL

      http://www.jpn-geriat-soc.or.jp/publications/journal/index.html

    • Peer Reviewed
  • [Journal Article] New quantitative total protein S assay system for diagnosing protein S type II : clinical application of the screening system for protein S type II deficiency2012

    • Author(s)
      Tsuda T., Jin X., Tsuda H., Ieko M., Morishita E., Adachi A., Hamasaki N.
    • Journal Title

      Blood Coagul Fibrinolysis.

      Volume: 23 (1) Pages: 56-63

    • DOI

      10.1097/MBC.0b013e32834ddefd

    • Peer Reviewed
  • [Journal Article] 肥満とプロテインS2011

    • Author(s)
      津田博子
    • Journal Title

      臨床検査

      Volume: 55 (4) Pages: 403-406

    • URL

      http://www.igaku-shoin.co.jp/journalPortal.do?journalPortalId=54

  • [Journal Article] Resveratrol, a phytoestrogen found in red wine, down-regulates protein S expression in HepG2 cells2011

    • Author(s)
      Hiroto Y., Tadokoro K., Tsuda T., Nakazono E., Ohnaka K., Takayanagi R., Hamasaki N., Tsuda H.
    • Journal Title

      Thromb. Res

      Volume: 127 Pages: e1-e7

    • DOI

      10.1016/j.thromres.2010.09.010

  • [Presentation] Resveratrol and its dimers down-regulate protein S mRNA expression in HepG2 cells2013

    • Author(s)
      Tsuda H., Nakazono E., Sata S., Kishi A., Matsukawa T., Ohnuki K
    • Organizer
      XXIV Congr. Int. Soc. Thromb. Haemost.
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2013-07-02
  • [Presentation] An improved screening system for protein S type II deficiency : expanded versatility of total protein S activity assay2013

    • Author(s)
      Jin X., Tsuda T., Tsuda H., Hamasaki N.
    • Organizer
      XXIV Congr. Int. Soc. Thromb. Haemost.
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2013-07-01
  • [Presentation] Racial differences in genetic risk factors for venous thromboembolism."Plasma coagulation inhibitors"2013

    • Author(s)
      Tsuda H.
    • Organizer
      59^<th> Annual SSC Meeting of Int. Soc. Thromb. Haemost.
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2013-06-29
    • Invited
  • [Presentation] Discontinuation of impact-loading exercise is related to reduction of a calcaneus quantitative ultrasound parameter in young adult Japanese females : a 3-year follow-up study2013

    • Author(s)
      Nakazono E., Tsuda H. その他11名
    • Organizer
      2^<nd> Joint Meeting of the Int. Bone & Mineral Soc. and the Japanese Soc. for Bone & Mineral Res.
    • Place of Presentation
      Kobe
    • Year and Date
      2013-05-31
  • [Presentation] 女子大学生の入学後の骨量減少には運動の中止が関与する-3年間の追跡調査-2012

    • Author(s)
      中園栄里、津田博子
    • Organizer
      第10回大連合大会(第34回日本臨床栄養学会総会、第33回日本臨床栄養協会総会)
    • Year and Date
      2012-10-07
  • [Presentation] 臨床検査としての食事調査の標準化(現行評価法の比較検討)-その22012

    • Author(s)
      津田博子、今井克己
    • Organizer
      第10回大連合大会(第34回日本臨床栄養学会総会、第33会日本臨床栄養協会総会)シンポジウム「食の評価,臨床栄養の評価」
    • Place of Presentation
      東京
    • Year and Date
      2012-10-06
    • Invited
  • [Presentation] Charting of daily weight pattern introduced into group therapy reinforces the synergistic effect on weight reduction in obese patients2012

    • Author(s)
      Ueno H., Tsuda H. その他14名
    • Organizer
      16^<th> Int. Congr. Dietetics
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2012-09-06
  • [Presentation] Total protein S assay system : Clinical significance and pre-analytical quality control."Plasma coagulation inhibitors"2012

    • Author(s)
      Tsuda H., Kobayashi T., Tsuda T.
    • Organizer
      58^<th> Annual SSC Meeting of Int. Soc. Thromb. Haemost.
    • Place of Presentation
      Liverpool, UK, June
    • Year and Date
      2012-06-28
    • Invited
  • [Presentation] アジア人特有の血栓性素因プロテインS異常症-新しい診断法の開発-2012

    • Author(s)
      津田博子
    • Organizer
      第34回日本血栓止血学会学術集会、ランチョンセミナー
    • Place of Presentation
      東京
    • Year and Date
      2012-06-09
    • Invited
  • [Presentation] 肥満女性における血液凝固制御因子プロテインSの血中動態の解析2012

    • Author(s)
      植田麻衣子、中園栄里、津田友秀、金秀日、中野修治、津田博子
    • Organizer
      第34回日本血栓止血学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-08
    • Invited
  • [Presentation] アジア人特有の血栓性素因-プロテインS異常症-2012

    • Author(s)
      津田博子、濱崎直孝
    • Organizer
      第6回日本血栓止血学会学術標準化委員会シンポジウム血栓性素因部会「新しいプロテインS活性測定法の開発」
    • Place of Presentation
      東京
    • Year and Date
      2012-01-21
    • Invited
  • [Presentation] 食行動の領域別解析からみた女性肥満症患者の摂取内容と代謝異常の関連2012

    • Author(s)
      上野宏美、津田博子、その他14名
    • Organizer
      第11回日本病態栄養学会総会
    • Place of Presentation
      京都
    • Year and Date
      2012-01-15
  • [Presentation] 臨床検査としての食事調査の標準化(現行評価法の比較検討)2011

    • Author(s)
      津田博子、今井克己
    • Organizer
      第9回大連合大会(第33回日本臨床栄養学会総会、第32会日本臨床栄養協会総会)シンポジウム「食の評価」
    • Place of Presentation
      東京
    • Year and Date
      2011-10-29
    • Invited
  • [Presentation] 最近の葉酸研究-生活習慣病との関連-2011

    • Author(s)
      津田博子
    • Organizer
      第30回日本思春期学会学術集会、ランチョンセミナー
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-27
    • Invited
  • [Presentation] Resveratrol, a phytoestrogen found in red wine, down-regulates protein S expression in HepG2 cells2011

    • Author(s)
      Tsuda H., Hiroto Y., Tadokoro K., Tsuda T., Nakazono E., Ohnaka K., Takayanagi R., Hamasaki N.
    • Organizer
      XXIII Congr. Int. Soc. Thromb. Haemost
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-07-28
  • [Presentation] Development of A New Quantitative Total Protein S Assay System for Screening of Protein S Type II deficiency2011

    • Author(s)
      Jin X., Tsuda T., Tsuda H., Ikeo M., Adachi T., Hamasaki N.
    • Organizer
      XXIII Congr. Int. Soc. Thromb. Haemost
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-07-28
  • [Presentation] Plasma concentrations of total protein S antigen are not related with body fat mass but with triglyceride levels in obese Japanese women2011

    • Author(s)
      Ueda M., Nakazono E., Tsuda T., Jin X., Nakano S., Tsuda H.
    • Organizer
      XXIII Congr. Int. Soc. Thromb. Haemost
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-07-28
  • [Presentation] Evaluation of a novel total Protein S assay system for screening of protein S type II deficiency,"Plasma coagulation inhibitors"2011

    • Author(s)
      Tsuda T., Jin X., Tsuda H., Morishita E., Kobayashi T., Hamasaki N.
    • Organizer
      57^<th> Annual SSC Meeting of Int. Soc. Thromb. Haemost.
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-07-27
  • [Presentation] New Quantitative Total Protein S Assay System for Diagnosing of Protein S type II Deficiency2011

    • Author(s)
      Tsuda T., Jin X., Tsuda H., Hamasaki N.
    • Organizer
      21^<st> International Congress of Clinical Chemistry and Laboratory Medicine
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2011-05-16
  • [Presentation] A Clinical Application of the Screening System for Protein S type II Deficiency2011

    • Author(s)
      Tsuda H., Morishita E., Kobayashi T., Tsuda T., Jin X., Hamasaki N.
    • Organizer
      21^<st> International Congress of Clinical Chemistry and Laboratory Medicine
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2011-05-15
  • [Presentation] 肥満女性の血中アディポネクチン濃度と体脂肪量、血中因子および食事因子の関連性-閉経前後での検討-2011

    • Author(s)
      宮崎瞳、津田博子、その他14名
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
  • [Book] 第8章成人期(戸谷誠之、伊藤節子、渡邊令子編:応用栄養学[改訂第4版]2012

    • Author(s)
      津田博子
    • Total Pages
      209-250/388
    • Publisher
      南江堂
  • [Book] 第1章疾患診断の概要、付表主要臨床検査基準値(田中明、加藤昌彦編: Nブックス・疾病の成り立ち:臨床医学)2012

    • Author(s)
      津田博子
    • Total Pages
      5-17, 191-195/201
    • Publisher
      建帛社
  • [Book] 第1章栄養ケア・マネジメント第1?3節、第7章高齢期の栄養(江澤郁子、津田博子編: Nブックス・三訂応用栄養学)2011

    • Author(s)
      津田博子
    • Total Pages
      1-14, 179-200/253
    • Publisher
      建帛社

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Published: 2015-07-16  

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