2013 Fiscal Year Final Research Report
A genome-wide screenig of autoantibody for eating disorders using the protein active array
| Project/Area Number |
23590908
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | National Center of Neurology and Psychiatry |
|---|
Principal Investigator |
ANDO Tetsuya 独立行政法人国立精神・神経医療研究センター, 精神保健研究所・心身医学研究部, 室長 (50311428)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
GOSHIMA Naoki 独立行政法人産業技術総合研究所創薬分子プロファイリング研究センター, 細胞システム制御解析チーム (70215482)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 摂食障害 / 神経性無食欲症 / 神経性大食症 / 肥満 / プロテインアレイ / 自己抗体 / 蛋白質 / 抗原 |
|---|
| Research Abstract |
Serum autoantibodies specific for eating disorders were screened using a protein array loaded with approximately 20,000 proteins, and 355 positive spots were detected. Of those, 180 antigens showing the strong signal were subjected to further confirmation in independent samples of eating disorder, obesity and healthy control. Forty seven antigens showed the positive signal in the anorexia nervosa sample, while negative in the control sample. The antigens with high positive rates included proteins which play a role in intracellular trafficking, regulation of G protein signaling, gastrointestinal functions and food intake, and neuroendocrine stress responses. A gene set analysis indicated that the positive antigens were included significantly more often in the gene set of Hormone_Activity.
|
-
[Journal Article] Association of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population2014
Author(s)
Ando T, Tamura N, Mera T, Morita C, Takei M, Nakamoto C, Koide M, Hotta M, Naruo T, Kawai K, Nakahara T, Yamaguchi C, Nagata T, Ookuma K, Okamoto Y, Yamanaka T, Kiriike N, Ichimaru Y, Ishikawa T, Komaki G, The Japanese Genetic Research Group For Eating Disorders
-
Journal Title
Molecular Genetics & Genomic Medicine
Volume: (Article first published online 24 FEB 2014)
DOI
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Integrated View of the Human Chromosome X-centric Proteome Project2013
Author(s)
Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T, Kodera Y, Sato Y, Araki N, Mamitsuka H, and Goshima N
-
Journal Title
J. Proteome Res
Volume: 12
Pages: 58-61
DOI
Peer Reviewed
-
[Journal Article] No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese2012
Author(s)
Ando T, Ishikawa T, Hotta M, Naruo T, Okabe K, Nakahara T, Takii M, Kawai K, Mera T, Nakamoto C, Takei M, Yamaguchi C, Nagata T, Okamoto Y, Ookuma K, Koide M, Yamanaka T, Murata S, Tamura N, Kiriike N, Ichimaru Y, Komaki G and the Japanese Genetic Research Group For Eating Disorders
-
Journal Title
Am J Med Genet Part B
Volume: 159B
Pages: 48-52
DOI
Peer Reviewed
-
[Journal Article] CAXII Is a Sero-Diagnostic Marker for Lung Cancer2012
Author(s)
Kobayashi M, Matsumoto T,Ryuge S, Yanagita K, Nagashio R, Kawakami Y, Goshima N, Jiang S-X, Saegusa M, Iyoda A, Satoh Y, Masuda N, and Sato Y
-
Journal Title
PLoS ONE
Volume: 7(3)
Pages: e33952
DOI
Peer Reviewed
-
[Journal Article] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer2012
Author(s)
Okabayashi K, Fujita T, Miyazaki J, Okada T, Iwata T, Hirao N, Noji S, Tsukamoto N, Goshima N, Hasegawa H, Takeuchi H, Ueda M, Kitagawa Y, Kawakami Y
-
Journal Title
Cancer Sci
Volume: 103(9)
Pages: 1617-1624
DOI
Peer Reviewed
-
-
[Presentation] 脂肪酸アミド加水分解酵素(FAAH)遺伝子385C/A多型と神経性食欲不振症との関連2013
Author(s)
安藤哲也,田村奈穂,米良貴嗣,河合啓介,武井美智子,中本智恵美,鈴木(堀田)眞理,成尾鉄朗,石川俊男,小牧元
Organizer
第17回日本摂食障害学会・学術集会
Place of Presentation
神戸市産業振興センター,神戸
Year and Date
20131102-03
-
[Presentation] 神経性食欲不振症の血漿アミノ酸プロファイルの解析2013
Author(s)
安藤哲也,田村奈穂,倉尚樹,小西恵,富田吉敏,知場奈津子,本間洋州,濱田孝,石川俊男,小牧元
Organizer
第54回日本心身医学会学術講演会
Place of Presentation
パシフィコ横浜,横浜
Year and Date
20130626-27
-
[Presentation] 神経性食欲不振症の血漿アミノ酸濃度の解析2012
Author(s)
安藤哲也,田村奈穂,倉尚樹,東風谷祐子,小西恵,富田吉敏,知場奈津子,庭瀬亜香,濱田孝,杤久保修,市丸雄平,石川俊男,小牧元
Organizer
第16回日本摂食障害学会学術集会
Place of Presentation
政策医療大学院大学,港区,東京
Year and Date
20121006-07
-
-
[Presentation] 神経性食欲不振症における血漿アミノ酸濃度プロフィールの検討2011
Author(s)
安藤哲也,田村奈穂,山本浩史,倉尚樹,小西恵,富田吉敏,田中孝幸,知場奈津子,庭瀬亜香,濱田孝,杤久保修,石川俊男,小牧元
Organizer
第16回日本心療内科学会総会・学術大会
Place of Presentation
東京国際交流館・プラザ平成,東京
Year and Date
20111126-27
-
[Presentation] 摂食障害遺伝子解析研究協力者会議脳由来神経栄養因子遺伝子の多型と神経性食欲不振症との関連の検討2011
Author(s)
安藤哲也,石川俊男,鈴木(堀田)眞理,成尾鉄朗,岡部憲二郎,中原敏博,瀧井正人,河合啓介,米良貴嗣,中本智恵美,武井美智子,山口力,永田利彦,岡本百合,大隈和喜,小出将則,山中隆夫,田村奈穂,切池信夫,小牧元
Organizer
第52回日本心身医学会総会ならびに学術講演会
Place of Presentation
パシフィコ横浜,横浜
Year and Date
20110609-10
-
-
