2013 Fiscal Year Final Research Report
Mechanism of Gastric Carcinogenesis in the progression to mucosal atrophy and intestinal metaplasia through Notch1 signaling
| Project/Area Number |
23590910
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
IMATANI AKIRA 東北大学, 医学(系)研究科(研究院), 教授 (30333876)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胃 / Helicobacter pylori / 癌抑制遺伝子 / 分化制御 |
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| Research Abstract |
H.pylori infection causes the precancerous gastric mucosal atrophy. A transmembrane receptor Notch1 promotes differentiation and maintenance of stem cells. In vitro and in vivo analyses in this study revealed that H.pylori infection triggered Notch1 suppression, leading to the gastric mucosal atrophy through the down-regulation of Sox2. In addition, loss-of-function of Notch1 signaling may contribute to gastric carcinogenesis.
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