2013 Fiscal Year Final Research Report
Establishment of early diagnosis method for esophageal cancer by mass spectrometry
| Project/Area Number |
23590915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 食道がん / 質量分析計 / メタボロミクス |
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| Research Abstract |
In this study, we performed metabolome analysis of esophageal cancer patients, and the aim of this study was to discover the biomarkers that are useful for early detection of esophageal cancer. As a result, we found the 17 metabolites that were significantly changed by the pathogenesis of esophageal cancer by metabolome analysis using gas chromatography/mass spectrometry. By lipid metabolome analysis using liquid chromatography/mass spectrometry, we discovered the 47 lipid metabolites with the significant alterations, and by cation/anion metabolome analysis using liquid chromatography/mass spectrometry, we found the 13 metabolites with the significant alterations. These significantly-changed metabolites may be candidates for esophageal cancer biomarkers.
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