2013 Fiscal Year Final Research Report
Evaluation of the functional role of Notch signaling in the development of Barrett's esophagus: interaction with Cdx2 pathway
| Project/Area Number |
23590917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AMANO Yuji 国際医療福祉大学, 保健医療学部, 教授 (80284032)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バレット食道 / シグナル伝達 / Notchシグナル / Cdx2 |
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| Research Abstract |
The relationship between the Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus has not been explored. The aim of this study was to investigate the interrelationship between Notch signaling and Cdx2 in esophageal epithelial cells. Forced expression of Cdx2 in cells suppressed Hes1, and enhanced ATOH1, Dll-1 and MUC2 expressions, whereas bile acids suppressed Hes1, and enhanced ATOH1, Dll-1, Cdx2, and MUC2 expressions. On the other hand, these effects were blocked by siRNA-based Cdx2 downregulation. We also found that both ATOH1 and Cdx2 expression were enhanced during development of Barrett's esophagus in rat model. Collectively, enhanced expression of Cdx2 by stimulation with bile acids may induce intestinal differentiation of esophageal columnar cells by interaction with the Notch signaling pathway including ATOH1 and Dll-1.
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[Journal Article] Crosstalk between TLR5 and Notch1 signaling in epithelial cells during intestinal inflammation2013
Author(s)
Aziz M, Ishihara S, Ansary MU, Sonoyama H, Tada Y, Oka A, Kusunoki R, Tamagawa Y, Fukuba N, Mishima Y, Mishiro T, Oshima N, Moriyama I, Ishimura N, Sato S, Yuki T, Kawashima K, Kinoshita Y
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Journal Title
Int J Mol Med
Volume: 32
Pages: 1051-62
DOI
Peer Reviewed
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[Journal Article] Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis2013
Author(s)
Kinoshita Y, Furuta K, Ishimura N, Ishihara S, Sato S, Maruyama R, Ohara S, Matsumoto T, Sakamoto C, Matsui T, Ishikawa S, Chiba T
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Journal Title
J Gastroenterol
Volume: 43
Pages: 333-339
URL
Peer Reviewed
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[Journal Article] IGICS Study Group : Questionnaire-based survey conducted in 2011 concerning endoscopic management of Barrett's esophagus in East Asian countries2012
Author(s)
Ishimura N, Amano Y, Sollano JD, Zhu Q, Kachintorn U, Rani AA, Hahm KB, Takahashi S, Arakawa T, Joh T, Matsumoto T, Naito Y, Suzuki H, Ueno F, Fukudo S, Fujiwara Y, Kamiya T, Uchiyama K, Kinoshita Y
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Journal Title
Digestion
Volume: 86
Pages: 136-146
DOI
Peer Reviewed
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[Journal Article] Capnographic monitoring for carbon dioxide insufflation during endoscopic submucosal dissection : comparison of transcutaneous and end-tidal capnometers2012
Author(s)
Kusunoki R, Amano Y, Yuki T, Oka A, Okada M, Tada Y, Uno G, Moriyama I, Ishimura N, Ishihara S, Kinoshita Y
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Journal Title
Surg Endosc
Volume: 26
Pages: 501-506
DOI
Peer Reviewed
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[Journal Article] Barrett's esophagus : endoscopic diagnosis2011
Author(s)
Ishimura N, Amano Y, Appelman HD, Penagini R, Tenca A, Falk GW, Wong RK, Gerson LB, Ramirez FC, Horwhat JD, Lightdale CJ, DeVault KR, Freschi G, Taddei A, Bechi P, Ringressi MN, Castiglione F, Rossi Degl'Innocenti D, Wang HH, Huang Q, Bellizzi AM, Lisovsky M, Srivastava A, Riddell RH, Johnson LF, Saunders MD, Chuttani R
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Journal Title
Ann N Y Acad Sci
Volume: 1232
Pages: 53-75
DOI
Peer Reviewed
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[Journal Article] Barrett's esophagus : proton pump inhibitors and chemoprevention I2011
Author(s)
Triadafilopoulos G, Taddei A, Bechi P, Freschi G, Ringressi MN, Degli'Innocenti DR, Castiglione F, Masini E, Majewski M, Wallner G, Sarosiek J, Dillon JF, McCallum RC, Dvorak K, Goldman A, Woodland P, Sifrim D, Richter JE, Vieth M, Neumann H, Langner C, Ishimura N, Amano Y, Felix VN
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Journal Title
Ann N Y Acad Sci
Volume: 1232
Pages: 93-113
DOI
Peer Reviewed
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[Journal Article] Fatty acid synthase expression in Barrett's esophagus : implications for carcinogenesis2011
Author(s)
Ishimura N, Amano Y, Sanchez-Siles AA, Fukuhara H, Takahashi Y, Uno G, Tamagawa Y, Mishima Y, Yuki T, Ishihara S, Kinoshita Y
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Journal Title
J Clin Gastroenterology
Volume: 45
Pages: 665-672
DOI
Peer Reviewed
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