2013 Fiscal Year Final Research Report
Association between Helicobacter pylori infection and bronchial asthma
| Project/Area Number |
23590924
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
ARAKAWA Tetsuo 大阪市立大学, 医学(系)研究科(研究院), 教授 (60145779)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292)
TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768)
WATANABE Toshio 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
TANIGAWA Tetsuya 大阪市立大学, 大学院医学研究科, 講師 (70423879)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヘリコバクター・ピロリ / 気管支喘息 |
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| Research Abstract |
Helicobacter pylori infection is pathogens associated with gastritis, peptic ulcers, and gastric cancer. However, epidemiological studies showed a negative association between H. pylori infection and development of bronchial asthma. The aim of the present project was to determine whether H. pylori infection affects development of bronchial asthma in an animal model. We examined effect of H. pylori infection on severity of ovalbumin- induced asthma in Mongolian gerbil. Ovalbumin induced similar severity of asthma, infiltration of inflammatory cells, cytokines, histological changes in both H. pylori infected and non-infected mice. H. pylori infection might not be associated with development of bronchial asthma.
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[Journal Article] Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients2014
Author(s)
Watanabe T, Tanigawa T, Shiba M, Nadatani Y, Nagami Y, Sugimori S, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Koike T, Arakawa T
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Gut
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Pages: 409-14
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[Journal Article] Rebamipide inhibits indomethacin-induced small intestinal injury : possible involvement of intestinal microbiota modulation by upregulation ofα-defensin 52013
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Tanigawa T, Watanabe T, Otani K, Nadatani Y, Ohkawa F, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
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Author(s)
Nadatani Y, Watanabe T, Tanigawa T, Ohkawa F, Takeda S, Higashimori A, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
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Journal Title
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Pages: e80130
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[Journal Article] A multicenter study on the prevalence of Eosinophilic Esophagitis and PPI-responsive esophageal eosinophilic infiltration2012
Author(s)
Fujiwara Y, Sugawa T, Tanaka F, Tatsuwaki H, Okuyama M, Hayakawa T, Yamamori K, Wada R, Ohtani K, Uno H, Tanigawa T, Watanabe Y, Tominaga K, Watanabe T, Takaishi O, Saeki Y, Nebiki H, Oshitani N, Sato H, Arakawa T
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Volume: 51
Pages: 3235-9
DOI
Peer Reviewed
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[Journal Article] Toll-like receptor 9 signaling has anti -inflammatory effects on the early phase of Helicobacter pylori-induced gastritis2012
Author(s)
Otani K, Tanigawa T, Watanabe T, Nadatani Y, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T
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Journal Title
Biochem Biophys Res Commun
Volume: 426
Pages: 342-9
DOI
Peer Reviewed
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[Journal Article] Role of Th-2 cytokines in the development of Barrett's esophagus in rats2011
Author(s)
Kohata Y, Fujiwara Y, Machida H, Okazaki H, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Wei M, Wanibuchi H, Arakawa T
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Journal Title
J Gastroenterol
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DOI
Peer Reviewed
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[Journal Article] Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease2011
Author(s)
Morimoto K, Hosomi S, Yamagami H, Watanabe K, Kamata N, Sogawa M, Machida H, Okazaki H, Tanigawa T, Nagahara H, Noda E, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T
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Journal Title
Scand J Gastroenterol
Volume: 46
Pages: 701-9
DOI
Peer Reviewed
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