2013 Fiscal Year Final Research Report
The role of Klotho, anti-aging molecule, in chronic gastritis and gastric carcinogenesis
| Project/Area Number |
23590925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
TANIGAWA Tetsuya 大阪市立大学, 医学(系)研究科(研究院), 講師 (70423879)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Toshio 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768)
FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292)
MACHIDA Hirohisa 大阪市立大学, 大学院医学研究科, 医員 (00382078)
ARAKAWA Tetsuo 大阪市立大学, 大学院医学研究科, 教授 (60145779)
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| Research Collaborator |
OTANI Koji 大阪市立大学, 大学院医学研究科, 研究医
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| Project Period (FY) |
2011 – 2013
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| Keywords | Klotho / ヘリコバクター・ピロリ / 萎縮性胃炎 / 胃潰瘍 / TLR9 / 胃発がん / 炎症 / 老化 |
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| Research Abstract |
The klotho gene was originally identified as an aging suppressor gene. We investigated whether Klotho is involved in pathophysiology in the stomach diseases. (Study 1) Gastric ulcer is associated with Helicobacter pylori (Hp) infection. During gastric ulcer healing, expression of mRNA for Klotho in gastric epithelial cells at the ulcer margin was reduced compared with normal gastric tissue. Administration of recombinant Klotho accelerated gastric ulcer healing. (Study 2) We investigated the expression and role of TLR9 in H. pylori-induced gastritis in mice. Our findings suggest that TLR9 signaling plays important roles in the suppression of H. pylori-induced gastric mucosal inflammation in the early phase via downregulation of TNF-alpha modulated by IFN-alpha1. (Study 3) Expression of mRNA for Klotho was downregulated in Hp-infected mice compared uninfected mice, suggesting the promotion of atrophy and carcinogenesis of the stomach .
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[Journal Article] 胃潰瘍治癒過程におけるアンチエイジング分子Klothoの発現動態と胃潰瘍治癒に及ぼす影響2013
Author(s)
谷川徹也, 渡辺俊雄, 灘谷祐二, 大谷恒史, 十河光栄, 山上博一, 斯波将次, 渡辺憲治, 富永和作, 藤原靖弘, 荒川哲男
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Journal Title
潰瘍
Volume: 40巻
Pages: 64-68
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[Journal Article] Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis2012
Author(s)
Otani K, Tanigawa T, Watanabe T, Nadatani Y, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T
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Journal Title
Biochem Biophys Res Commun
Volume: 426
Pages: 342-349
DOI
Peer Reviewed
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[Journal Article] Toll-like receptor 9シグナルはHelicobacter pylori誘発胃炎の初期過程において抗炎症効果を有する2012
Author(s)
谷川徹也, 大谷恒史, 渡辺俊雄, 灘谷祐二, 岡崎博俊, 町田浩久, 山上博一, 渡辺憲治, 富永和作, 藤原靖弘, 荒川哲男
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Journal Title
消化器と免疫
Volume: 48
Pages: 97-100
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[Journal Article] Klotho, an Aging Suppressor, and Fibroblast Growth Factor 23 is Involved in Gastric Ulcer Healing2012
Author(s)
Tetsuya Tanigawa, Toshio Watanabe, Yuji Nadatani, Koji Otani, Hirohisa Machida, Hirotoshi Okazaki, Hirokazu Yamagami, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Tetsuo Arakawa
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Journal Title
Gastroenterology
Volume: 142;Supple1
Pages: S-493
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