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2013 Fiscal Year Final Research Report

The role of single nucleotide polymorphism of COX-2 gene in the progression of chronic gastritis

Research Project

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Project/Area Number 23590927
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionNippon Medical School

Principal Investigator

SAKAMOTO Choitsu  日本医科大学, 医学(系)研究科(研究院), 教授 (30196092)

Project Period (FY) 2011 – 2013
Keywords慢性胃炎 / シクロオキシゲナーゼ2 / 遺伝子単塩基変異
Research Abstract

We investigated to see how single nucleotide polymorphism (SNP) of cyclooxygenase(COX)-2 and IL-1 beta genes is involved in the progression of Helicobacter pylori(Hp) gastritis to strophic gastritis, comparing SNP (COX-2SNP rs689466, IL-1 betaSNP rs16944) and atrophic scores determined by histrolgy. Activity, inflammation, atrophy and intestinal metaplasma in Hp-gastritis mucosa were histologideally scored as 0-3 according to Updated Sydney system. 1L-1betaSNP-511T/T was shown to be correlated with the progression of strophic gastritis as previously reported. However, COX-2 gene SNP -1195 was not found to be correlated with strophic gastritis in the present study.

  • Research Products

    (13 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues2014

    • Author(s)
      Nagoya H, Futagami S, Shimpuku M, et al. (計14名)
    • Journal Title

      AM J Physiol Gastrointest Liver Physiol

      Volume: Vol.306 No. 3 Pages: G183-90

    • DOI

      10.1152/ajpgi.00057.2013

    • Peer Reviewed
  • [Journal Article] Impact of sleep disorders, quality of life and gastric emptying in distinct subtypes of functional dyspepsia in Japan2014

    • Author(s)
      Yamawaki H, Futagami S, Shimpuku M, et al. (計11名)
    • Journal Title

      J Neurogastroenterol Motil

      Volume: Vol. 20 No. 1 Pages: 104-12

    • DOI

      10.5056/jnm.2014.20.1.104

    • Peer Reviewed
  • [Journal Article] The preproghrelin 3056 TT genotype is associated with the feeling of hunger and low acylated ghrelin levels in japanese patients with Helicobacter Pylori-negative functional dyspepsia2013

    • Author(s)
      Futagami S, Shimpuku M, Kawagoe T, et al (計13名)
    • Journal Title

      Intern Med

      Volume: Vol52 No.11 Pages: 1155-63

    • DOI

      10.2169/internalmedicine.52.8662

    • Peer Reviewed
  • [Journal Article] Nizatidine Improves Clinical Symptoms and Gastric Emptying in Patients with Functional Dyspepsia Accompanied by Impaired Gastric Emptying2012

    • Author(s)
      Futagami S, Shimpuku M, Song JM, Kodaka Y, et al. (計12名)
    • Journal Title

      Digestion

      Volume: Vol. 86 No.2 Pages: 114-21

    • DOI

      10.1159/000339111

    • Peer Reviewed
  • [Journal Article] G-proteinβ3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese2011

    • Author(s)
      Shimpuku M, Futagami S, Kawagoe T, et al.(計9名)
    • Journal Title

      Neurogastroenterol Motil

      Volume: Vol. 23 No. 12 Pages: 1073-80

    • DOI

      10.1111/j.1365-2982.2011.01781.x

    • Peer Reviewed
  • [Journal Article] Efficacy and safety of the selective cyclooxygenase-2 inhibitor celecoxib in the treatment of rheumatoid arthritis and osteoarthritis in Japan2011

    • Author(s)
      Sakamoto C, Soen S
    • Journal Title

      Digestion

      Volume: Vol. 83 No.1-2 Pages: 108-23

    • DOI

      10.1159/000318746

    • Peer Reviewed
  • [Presentation] H. pylori陽性胃炎患者におけるCOX-2のSNPを用いた除菌後ハイリスク群の絞り込み2014

    • Author(s)
      小高康裕, 二神生爾, 坂本長逸
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-24
  • [Presentation] H.pylori陽性胃炎患者におけるCOX-2のSNPを用いた除菌後ハイリスク群の絞り込み2013

    • Author(s)
      小高康裕, 二神生爾, 辰口篤志, その他(計13名)
    • Organizer
      第55回日本消化器病学会大会(JDDW)
    • Place of Presentation
      東京
    • Year and Date
      2013-10-10
  • [Presentation] 食道癌組織においてROS刺激下に誘導されるApurinic/apyrimidinic endonuclease-1(APE-1)およびCOX-2発現意義の解析2012

    • Author(s)
      名児耶浩幸, 二神生爾, 坂本長逸
    • Organizer
      第54回日本消化器病学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-10
  • [Presentation] Heregulin, an agonist of erb3 or erb4, expression linked to a COX-2-PEG2 pathway in fibroblasts possibly plays a role in ulcer repair process in humans2012

    • Author(s)
      Sakamoto C
    • Organizer
      7th International Symposium on Cell/Tissue Injury and Cytoprotection/ Organoprotection
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2012-09-10
  • [Presentation] CD44陽性胃癌幹細胞のCOX-2発現の解析2012

    • Author(s)
      山脇博士, 二神生爾, 河越哲郎, その他(計11名)
    • Organizer
      第18回日本ヘリコバクター学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2012-06-29
  • [Presentation] 消化管粘膜傷害とシクロオキシゲナーゼ(COX)-2の役割2011

    • Author(s)
      坂本長逸
    • Organizer
      第48回日本臨床生理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-04
    • Invited
  • [Presentation] H. pylori陽性胃炎患者に対するCOX-2遺伝子多型を用いたハイリスク群の絞り込みの検討2011

    • Author(s)
      小高康裕,二神生爾,新福摩弓,その他(計11名)
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14

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Published: 2015-07-16  

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