2013 Fiscal Year Final Research Report
The role of single nucleotide polymorphism of COX-2 gene in the progression of chronic gastritis
| Project/Area Number |
23590927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SAKAMOTO Choitsu 日本医科大学, 医学(系)研究科(研究院), 教授 (30196092)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性胃炎 / シクロオキシゲナーゼ2 / 遺伝子単塩基変異 |
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| Research Abstract |
We investigated to see how single nucleotide polymorphism (SNP) of cyclooxygenase(COX)-2 and IL-1 beta genes is involved in the progression of Helicobacter pylori(Hp) gastritis to strophic gastritis, comparing SNP (COX-2SNP rs689466, IL-1 betaSNP rs16944) and atrophic scores determined by histrolgy. Activity, inflammation, atrophy and intestinal metaplasma in Hp-gastritis mucosa were histologideally scored as 0-3 according to Updated Sydney system. 1L-1betaSNP-511T/T was shown to be correlated with the progression of strophic gastritis as previously reported. However, COX-2 gene SNP -1195 was not found to be correlated with strophic gastritis in the present study.
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