2013 Fiscal Year Final Research Report
Protective role of Reg protein on mucosal injury in the gastrointestinal tract
| Project/Area Number |
23590929
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIWA Hiroto 兵庫医科大学, 医学部, 教授 (80190833)
WATARI Jiro 兵庫医科大学, 医学部, 教授 (10311531)
OSHIMA Tadayuki 兵庫医科大学, 医学部, 講師 (00381814)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 遺伝子 / 再生医学 / 臨床 / 感染 / 癌 |
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| Research Abstract |
Reg protein may function as an antimicrobial peptide and its expression is significantly regulated by IL-22 stimulation. Furthermore, Reg protein functions a trophic and/or anti-apoptotic factor on not only epithelial but also endothelial cells in the gastrointestinal mucosa. These effects are advantageous to protect the gastrointestinal mucosal injury. However, in gastric cancer tissues the anti-apoptotic effect of dysregulated Reg protein may confer resistance to chemotherapeutic drugs in gastric cancer cells.
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[Journal Article] REG Iαis a biomarker for predicting response to chemotherapy with S-1 puls cisplatin in patients with unresectable stage IV gastric cancer2013
Author(s)
Sekikawa A, Fukui H, Zhang X, Maruo T, Tsumura T, Okabe Y, Wakasa T, Osaki Y, Chiba T, Tomita T, Oshima T, Watari J, Miwa H
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Journal Title
Br J Cancer
Volume: 108
Pages: 395-401
Peer Reviewed
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[Journal Article] Overexpression of regenerating gene Iαappears to reflect aberration of crypt cell compartmentalization in sessile serrated adenoma/polyps of the colon2013
Author(s)
Okamoto K, Fujimori T, Yamaguchi T, Ichikawa K, Tomita S, Imura J, Ohkura Y, Yao T, Fujii S, Kusaka T, Sekikawa A, Fukui H, Chiba T, Kato H, Mitomi H
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Journal Title
Diagn Pathol
Volume: 8
Pages: 187
Peer Reviewed
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[Journal Article] Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis2012
Author(s)
Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I
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Journal Title
Mod Rheumatol
Volume: 22
Pages: 228-237
Peer Reviewed
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[Journal Article] DMBT1 is a novel gene induced by IL-22 in ulcerative colitis2011
Author(s)
Fukui H, Sekikawa A, Tanaka H, Fujimori Y, Katake Y, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T, Fujimori T
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Journal Title
Inflam Bowel Dis
Volume: 17
Pages: 1177-1188
Peer Reviewed
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