2013 Fiscal Year Final Research Report
Regulation of mucosal immunity and homeostasis by epithelial cells and dendritic cells
| Project/Area Number |
23590933
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院, 助教 (90518945)
YAMADA Atsuo 東京大学, 医学部附属病院, 助教 (80534932)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 免疫 / シグナル伝達 / 腸内細菌 |
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| Research Abstract |
The aim of this study was to understand the roles of epithelial cell and dendritic cell in the regulation of immune responses and homeostasis in colon. Epithelial cell-specific IKK knockout mice showed comparable inflammatory responses to WT mice in Citrobacter-induced colitis. In contrast, hematopoietic IKK signals are critical to mucosal accumulation of dendritic cells and regulation of Citrobacter. Dendritic cell-specific TGFbR2 knockout mice showed severe gastrointestinal inflammation and died before 12 week. Dendritic cell-specific TGFbR2 heterozygote mice also exhibited susceptibility to Citrobacter-induced colitis. The results in this study indicate TGFb signaling on dendritic cells is an important regulator of colonic homeostasis by sensing and regulating microbiota of colon.
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