2013 Fiscal Year Final Research Report
Elucidation of activation mechanism of insulin-like growth factor and development of therapy using neutralizing antibody in the gastrointestinal cancers
| Project/Area Number |
23590939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | がん / シグナル伝達 / 分子標的薬 / インスリン様増殖因子 |
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| Research Abstract |
It is necessary for the cancer cells to adapt to the tissue microenvironment for the metastasis formation in other ogans. Colon cancer cells highly metastasize to the liver and control of liver metastasis is most important issue in the therapeutic strategy of colon cancer. We clarified that liver-derived insulin-like growth factors (IGFs) activated by cancer-producing protease play an important role for the liver metastasis formation and could be a therapeutic target using neutralizing antibody. Furthermore, we developed the measurement system of activted (bioactive) IGF in the blood and demonstrated that bioactive IGF was increased with progressio of liver metastais and could be a biomarker of IGF neutralizing strategy in the mouse model.
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