2013 Fiscal Year Final Research Report
Role of iron as an detrimental influence on inflammatory bowel disease -analysis based on enteric microbiota and iron-related molecules
| Project/Area Number |
23590940
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
MATSUURA MINORU 京都大学, 医学(系)研究科(研究院), 助教 (30402910)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 炎症性腸疾患 / 環境因子 / 鉄 / 腸内細菌 |
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| Research Abstract |
Diet is a potential environmental influence in inflammatory bowel diseases (IBD). Enteric bacteria are required to induce and perpetuate intestinal inflammation in IBD, and iron is essential for the growth and virulence of bacteria. IL-10 deficient mice were fed normal- or low-iron diets. Histologic inflammation in the low-iron diet group was ameliorated and colonic IL-12p40 and MLN IL-17 secretion was lower in mice fed low-iron diet. There was no significant difference in concentrations of cultivable cecal bacteria, while T-RFLP analysis revealed distinct difference in the profile between two groups. The intracellular survival of iron-loaded E. coli in J774 macrophage cells was significantly enhanced compared to non-iron-loaded E. coli. TNF secretion from J774 cells phagocytosing iron-loaded E. coli was higher than J774 cells phagocytosing non-iron-loaded E. coli. Dietary iron potentiates intestinal inflammation by alteration of growth and virulence of enteric microbiota.
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[Journal Article] Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn's disease2014
Author(s)
Honzawa Y, Nakase H, Shiokawa M, Yoshino T, Imaeda H, Matsuura M, Kodama Y, Ikeuchi H, Andoh A, Sakai Y, Nagata K, Chiba T
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Establishment of a novel mouse model of ulcerative colitis with concomitant cytomegalovirus infection : in vivo identification of cytomegalovirus persistent infected cells2013
Author(s)
Matsumura K, Nakase H, Kosugi I, Honzawa Y, Yoshino T, Matsuura M, Kawasaki H, Arai Y, Iwashita T, Nagasawa T, Chiba T
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Journal Title
Inflamm Bowel Dis
Volume: 19
Pages: 1951-63
DOI
Peer Reviewed
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[Journal Article] Effect of intensive granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis positive for cytomegalovirus2013
Author(s)
Fukuchi T, Nakase H, Matsuura M, Yoshino T, Toyonaga T, Ohmori K, Ubukata S, Ueda A, Eguchi T, Yamashita H, Ito D, Ashida K
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Journal Title
J Crohns Colitis
Volume: 7
Pages: 803-11
DOI
Peer Reviewed
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[Journal Article] Rapid induction of mucosal healing by intensive granulocyte and monocyte adsorptive aphaeresis in active ulcerative colitis patients without concomitant corticosteroid therapy2011
Author(s)
Fukuchi T, Nakase H, Ito D, Yamashita H, Matsuura M, Nagatani Y, Koga H, Senda K, Eguchi T, Ubukata S, Kawaguchi S, Ueda A, Tanaka T, Ohashi R, Otzuka M, Ashida K
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Journal Title
Aliment Pharmacol Ther
Volume: 34
Pages: 583-5
DOI
Peer Reviewed
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[Journal Article] SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation2011
Author(s)
Uza N, Nakase H, Yamamoto S, Yoshino T, Takeda Y, Ueno S, Inoue S, Mikami S, Matsuura M, Shimaoka T, Kume N, Minami M, Yonehara S, Ikeuchi H, Chiba T
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Journal Title
Gut
Volume: 60
Pages: 1494-505
DOI
Peer Reviewed
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