Regenerative therapy using autogenic adipocyte-derived progenitor cells for radiation colitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590946
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Fukushima Medical University
• Principal Investigator: OHTSURU Akira 福島県立医科大学, 医学部, 教授 (00233198)
• Co-Investigator(Kenkyū-buntansha): ISOMOTO Hajime 長崎大学, 大学病院, 准教授 (90322304) ; MAKASHIMA Masahiro 長崎大学, 原爆後障害医療研修所, 教授 (50284683) ; YOSHIMOTO Hiroshi 長崎大学, 大学病院, 助教 (90513309)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 放射線晩発性障害 / スクリーニング / 多分化能 / 再生阻害局所環境

Outline of Final Research Achievements

Radiation-induced intestinal and skin injury is one of the most life-threatening diseases in acute radiation syndrome. Although there is no patient of acute radiation syndrome in Fukushima Daiichi Nuclear Power Plant (NPP) accident compared to past nuclear disaster, it is an important issue to discover how to reduce the radiation-induced skin and intestinal damage in preparation for accident medical responses in high dose circumstances for long-term reactor decommissioning. We have been developing a regenerative therapy system using non-cultured autologous adipose-derived stem cells. Furthermore, we have developed a novel system to generate multilineage progenitor cells from normal tissues. To establish a strategy for a rapid screening survey of surface contamination among a large number of people after NPP accidents, we analyzed the measured surface contamination of subjects. It is a strategy to screen a possible deterministic effect including radiation colitis.

Free Research Field

被ばく医療学