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2013 Fiscal Year Final Research Report

Research of Inflammatory Bowel Disease Based on Clinical Immunology and Endoscopy

Research Project

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Project/Area Number 23590949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKeio University

Principal Investigator

IWAO Yasushi  慶應義塾大学, 医学部, 教授 (40168547)

Co-Investigator(Kenkyū-buntansha) KANAI Takanori  慶應義塾大学, 医学部, 教授 (40245478)
Project Period (FY) 2011 – 2013
Keywords炎症性腸疾患 / alternative Th1 / 腸内細菌
Research Abstract

In CD4+CD45RBhigh adoptive transfer colitis model, we demonstrated that RORgt+ Th17 and Th17/Th1 cells become colitogenic alternative Th1 cells in vivo. Treg cells suppressed this pathway and development of intestinal inflammation. In addition, we found that Clostridium butyricum, which produces butyrate, suppress intestinal inflammation in mice colitis models. Interestingly, C. butyricum promoted IL-10 production by intestinal macrophage, but not Treg cells. Fecal 16S rRNA analysis, C. butyricum was decreased in the patients with IBD. Our findings provide the new insight into the mechanism of colitogenic T cell development in vivo and suggests the potential of Clostridium butyricum as a novel probiotics.

  • Research Products

    (10 results)

All 2014 2013 2012 2011

All Journal Article (8 results) Presentation (2 results)

  • [Journal Article] Endoscopic and pathologic changes of the upper gastrointestinal tract in Crohn's disease2014

    • Author(s)
      Sakuraba A, Iwao Y, Matsuoka K, Naganuma M, Ogata H, Kanai T, Hibi T
    • Journal Title

      Biomed Res Int

      Volume: 89(peer review) Pages: e610767

    • DOI

      10.1155/2014/610767

  • [Journal Article] Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation2014

    • Author(s)
      Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T
    • Journal Title

      PLoS One

      Volume: 9(peer review) Pages: e84619

    • DOI

      10.1371/journal.pone.0084619

  • [Journal Article] A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice2013

    • Author(s)
      Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hibi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T
    • Journal Title

      Cell Host Microbe

      Volume: 13(peer review) Pages: 711-22

    • DOI

      10.1016/j.chom.2013.05.013

  • [Journal Article] Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients2013

    • Author(s)
      Miyoshi J, Matsuoka K, Inoue N, Hisamatsu T, Ichikawa R, Yajima T, Okamoto S, Naganuma M, Sato T, Kanai T, Ogata H, Iwao Y, Hibi T
    • Journal Title

      J Crohns Colitis

      Volume: 7(peer review) Pages: e609-14

    • DOI

      10.1016/j.crohns.2013.04.018

  • [Journal Article] Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice2013

    • Author(s)
      Handa T, Kanai T, Sato T, Mikami Y, Sujino T, Hayashi A, Mizuno S, Matsumoto A, Hisamatsu T, Hibi T
    • Journal Title

      Immunol Lett

      Volume: 150(peer review) Pages: 23-9

    • DOI

      10.1016/j.imlet.2013.01.010

  • [Journal Article] Long-term prognosis of patients with ulcerative colitis treated with cytapheresis therapy2013

    • Author(s)
      Takayama T, Kanai T, Matsuoka K, Okamoto S, Sujino T, Mikami Y, Hisamatsu T, Yajima T, Iwao Y, Ogata H, Hibi T
    • Journal Title

      J Crohns Colitis

      Volume: 7(peer review) Pages: e49-54

    • DOI

      10.1016/j.crohns.2012.05.005

  • [Journal Article] Dysregulated balance of retinoid-related orphan receptorγt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis2012

    • Author(s)
      Kimura K, Kanai T, Hayashi A, Mikami Y, Sujino T, Mizuno S, Handa T, Matsuoka K, Hisamatsu T, Sato T, Hibi T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 427(peer review) Pages: 694-700

    • DOI

      10.1016/j.bbrc.2012.09.091

  • [Journal Article] Littman DR< Hibi T. Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells2011

    • Author(s)
      Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A
    • Journal Title

      Gastroenterology

      Volume: 141(peer review) Pages: 1014-23

    • DOI

      10.1053/j.gastro.2011.05.052

  • [Presentation] A Single Strain of Clostridium Butyricum Suppresses Intestinal Inflammation by Converting Activated Lamina Propria Cd11b+CD11cInt Macrophages to IL-10-Producing Regulatory Macrophages2012

    • Author(s)
      Hayashi A, et al
    • Organizer
      American Gastroenterology Association
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-05-21
  • [Presentation] Intestinal Microbiota is Essential for Both the Initiation and the Maintenance of Colitis,and Dysbiosis of IBD Patients2012

    • Author(s)
      Sujino T, et al
    • Organizer
      The 98th General Meeting of the Japanese Society of Gastroenterology
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-04-20

URL: 

Published: 2015-07-16  

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