2013 Fiscal Year Final Research Report
Role of a novel transcriptional repressor gene, ZFP-BA, in colon cancer proliferation and apoptosis
| Project/Area Number |
23590952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 大腸癌 / 上皮細胞増殖因子 / アンギオテンシンII受容体拮抗薬 |
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| Research Abstract |
ZFP-BA, a novel transcriptional repressor gene, degradation caused by interaction with the Heparin-binding epidermal growth factor-like growth factor-C-terminal fragment (HB-EGF-CTF) should induce some important factors for cell proliferation and inhibit others for cell apoptosis in colon cancers. The inhibition of interactions between HB-EGF-CTF and ZFP-BA is considered essential because agents that can inhibit HB-EGF-CTF translocation might suppress ZFP-BA downregulation.
Telmisartan, angiotensin II type 1 receptor blockers (ARBs), is one of the candidate inhibitors of HB-EGF-CTF nuclear translocation in vitro. However, treatment for humans with colon cancer would require high volume of telmisartan to prevent cell proliferation. The inhibition of HB-EGF-CTF nuclear translocation signaling will comprise a new strategy against the development of colorectal cancer. ZFP-BA might become one of the targets of future strategies to treat colon cancers.
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