The mechanism of action of strong anti-inflammatory effects in novel Lactobacillus probiotic strains isolated from Japanese "Funazushi"

2016 Fiscal Year Final Research Report

• Project/Area Number: 23590954
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: National Defense Medical College
• Principal Investigator: Okada Yoshikiyo 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 内科学, 助教 (90531137)
• Co-Investigator(Renkei-kenkyūsha): Hokari Ryota 防衛医科大学, 内科学講座, 教授 (90255464) ; Miura Soichiro 防衛医科大学, 学校長 (50138012)
• Research Collaborator: Tsuzuki Yoshikazu 埼玉医科大学, 消化管内科 (10236929)
• Project Period (FY): 2011-04-28 – 2017-03-31
• Keywords: 発酵食品 / プロバイオティクス / 抗炎症作用 / 炎症性腸疾患 / 樹状細胞 / 制御性T細胞

Outline of Final Research Achievements

We isolated novel Lactobacillus probiotic strains from "Funazushi" that is known to Japanese traditional fermented foods. Those strains showed strong anti-inflammatory effects on DSS-induced colitis than those of L.gasseri, conventional type of probiotics. Our data also suggest that a stronger anti-inflammatory effects of those strains on DSS-induced colitis are initiated by the phenotypic change in intestinal dendritic cells characterized high β8-integrin expression, leading to induce Tregs through induction of active-form of TGF-β mediated by those DCs.
Our results demonstrated that Japanese traditional fermented foods such as "Funazushi" are valuable source for probiotics that has strong anti-inflammatory effects compared to conventional type of probiotics.

Free Research Field

消化器内科学