2013 Fiscal Year Final Research Report
The role of nuclear receptor coactivator PDIP1 in non-alcholic steatohepatitis
| Project/Area Number |
23590959
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
Sato Ken 群馬大学, 医学部附属病院, 助教 (40396619)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
山崎 勇一 群馬大学, 医学(系)研究科(研究院), 助教 (00582404)
堀口 昇男 群馬大学, 医学部附属病院, 助教 (10550022)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SATOH tetsurou 群馬大学, 医学部附属病院, 講師 (40302484)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 脂質 / 病理学 / 発現制御 / 遺伝子 / 動物 |
|---|
| Outline of Final Research Achievements |
Methionine-choline-deficient diet (MCD diet) has been established to use to make an animal model of non-alchoholic steatohepatitis. In PPAR gamma DNA-binding domain-interacting protein1 (PDIP1) knockout mice, serum ALT and TG, and hepatic fatty deposition, inflammation, and fibrosis were significantly reduced compared to wild type mice. Besides, the expressions of hepatic lipid-related genes have changed and hepatic inflammatory cytokines and fibrogenic genes were significantly reduced compared to wild type mice. Thus, we showed that non-alchoholic steatohepatitis was ameliorated in PDIP1 knockout mice.
|
| Free Research Field |
医歯薬学
|
-
[Journal Article] Transforming growth factor-αactivates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation2013
Author(s)
Tahara H, Sato K, Yamazaki Y, Ohyama T, Horiguchi N, Hashizume H, Kakizaki S, Takagi H, Ozaki I, Arai H, Hirato J, Jesenofsky R, Masamune A, Mori M
-
Journal Title
Lab Invest
Volume: 93(6)
Pages: 720-32
-
-
-
-
-
-
-
-
-
-
-
-
-
-
