2013 Fiscal Year Final Research Report
Stimulation of liver regeneration and function by IGF-I
Project/Area Number |
23590961
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | The University of Tokyo |
Principal Investigator |
TOMIYA Tomoaki 東京大学, 医学部附属病院, 特任講師 (90227637)
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Co-Investigator(Kenkyū-buntansha) |
IKEDA Hitoshi 東京大学, 医学部附属病院, 准教授 (80202422)
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Project Period (FY) |
2011 – 2013
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Keywords | 再生医学 / 栄養学 / 肝不全 |
Research Abstract |
Stimulation of proliferation and function by hepatic cells are important for the treatment of liver failure. We studied the stimulatory effect of IGF-I on hepatic cells. IGF-I activated its receptor on hepatocytes, and stimulated its proliferation as well as protein production and glucose metabolism. These effects were regulated by culture conditions of hepatocytes. In hepatic stellate cells, IGF-I enhanced the proliferation, while collagen production was reduced by IGF-I treatment through the enhancement of collagen degradation.IGF-I stimulates hepatocyte proliferation and function. In addition, it may suppress hepatic fibrosis. IGF-I is a candidate as a drug for the treatment of liver diseases including hepatic failure.
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[Journal Article] High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly-malignant potential2014
Author(s)
Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Koike K, Yatomi Y, Ikeda H
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Journal Title
Int J Cancer
Volume: 134
Pages: 2189-2198
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[Journal Article] Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents2012
Author(s)
Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, Satoh Y, Shimosawa T, Shinozaki K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Yokota H, Koyama T, Ishimaru K, Okamoto Y, Takuwa Y, Koike K, Yatomi Y
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Journal Title
Hepatology
Volume: 56
Pages: 1427-38
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[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C2011
Author(s)
Ikeda H, Tateishi R, Enooku K, Yoshida H, Nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
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Journal Title
Cancer Epidemiol Biomarkers Prev
Volume: 20
Pages: 2204-11
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[Journal Article] Autotaxin as a novel serum marker of liver fibrosis2011
Author(s)
Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y
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Journal Title
Clin Chim Acta
Volume: 412
Pages: 1201-6
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[Presentation] 新たな肝線維化マーカーとしての血清Autotaxin抗原量2011
Author(s)
中川勇人, 池田均, 増崎亮太, 建石良介, 吉田晴彦, 渡邉尚子, 富谷智明, 井上有希子, 西川尚子, 大友夏子, 田上靖, 小池和彦
Organizer
第47回日本肝臓学会総会
Place of Presentation
東京
Year and Date
20110602-03
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[Presentation] 血中ADAMTS13による肝細胞癌発症予測2011
Author(s)
池田均, 建石良介, 榎奥健一郎, 吉田晴彦, 中川勇人, 増崎亮太, 近藤祐爾, 五藤忠, 椎名秀一朗, 富谷智明, 井上有希子, 西川尚子, 大友夏子, 田上靖, 小池和彦
Organizer
第47回日本肝臓学会総会
Place of Presentation
東京
Year and Date
20110602-03
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