2013 Fiscal Year Final Research Report
Effect of incretin for the liver
| Project/Area Number |
23590971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Mie University |
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Principal Investigator |
FUJITA Naoki 三重大学, 医学部附属病院, 講師 (80378398)
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| Project Period (FY) |
2011 – 2013
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| Keywords | インクレチン / 肝細胞 / 糖代謝 / 脂質代謝 / 肝脂肪化 |
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| Research Abstract |
Incretin is a naturally occurring peptide secreted by the L or K cells of the small intestine. Incretin regulates glucose-mediated insulin and glucagon productions by pancreatic beta and alpha cells. In this study, we demonstrated that incretin has a cognate receptors on human and mouse hepatocytes and that incretin has a direct effect on the reduction of hepatic steatosis in the absence of insulin. Incretin increased the phosphorylation of PDK-1, AKT, and protein kinase C in HepG2 and Huh7 cells. Incretin-treated hepatocytes resulted in a significant increase in cAMP production as well as reduction in mRNA expression of fatty acid synthesis-related genes. Finally, incretin treatment reversed hepatis statosis in mouse, but little effect occurred in hepatic fibrosis and cell proliferation. In conclusion, our data suggest that incretin has a novel direct effect on hepatocytes glucose and fat metabolism.
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Author(s)
Iwasa M, Iwata K, Hara N, Hattori A, Ishidome M, Sekiguchi-Fujikawa N, Mifuji-Moroka R, Sugimoto R, Fujita N, Kobayashi Y, Takei Y
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Author(s)
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Journal Title
Liver Int
Volume: 32
Pages: 675-688
Peer Reviewed
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